Results 131 to 140 of about 534,367 (396)

Key Connectomes and Synaptic‐Compartment‐Specific Risk Genes Drive Pathological α‐Synuclein Spreading

Advanced Science, EarlyView.
Utilizing a stereotaxic injection mouse model and a novel mathematical approach, this study uncovers key subnetworks that drive pathological α‐synuclein (α‐Syn) progression in Parkinson's disease (PD). Remarkably, just 2% of the strongest connections in the connectome are sufficient to predict its spread.
Yuanxi Li, Justin Torok, Shujing Zhang, Jessica Ding, Ning Wang, Courtney Lau, Shruti Kulkarni, Chaitali Anand, Julie Tran, Michael Cheng, Claire Lo, Binbin Lu, Yanzi Sun, Robert Damoiseaux, Xia Yang, Ashish Raj, Chao Peng   +16 more
wiley   +1 more source

Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[18F]fluoro-D-glucose positron emission and computed tomography

Nature Network Boston, 2016
Tuberculosis is classically divided into states of latent infection and active disease. Using combined positron emission and computed tomography in 35 asymptomatic, antiretroviral-therapy-naive, HIV-1-infected adults with latent tuberculosis, we ...
H. Esmail, R. Lai, M. Lesosky, K. Wilkinson, C. Graham, A. Coussens, T. Oni, J. Warwick, Q. Said-Hartley, C. Koegelenberg, G. Walzl, J. Flynn, D. Young, Clifton E. Barry, III, A. O’Garra, R. Wilkinson   +15 more
semanticscholar   +1 more source

Quantum Tomography Via Group Theory [PDF]

arXiv, 2000
Amongst the multitude of state reconstruction techniques, the so-called "quantum tomography" seems to be the most fruitful. In this letter, I will start by developing the mathematical apparatus of quantum tomography and, later, I will explain how it can be applied to various quantum systems.
arxiv  

BAG2 Inhibits Cervical Cancer Progression by Modulating Type I Interferon Signaling through Stabilizing STING

Advanced Science, EarlyView.
Based on IP‐MS analysis, BAG2 is confirmed to be essential for ubiquitination and protein homeostasis regulation of STING in cervical cancer. BAG2 inhibits the ubiquitination and degradation of STING by forming a complex with STUB1, thereby activating the type I IFN signaling pathway and inhibiting the development of cervical cancer.
Shijie Yao, Siming Chen, Anjin Wang, Ziyan Liang, Xuelian Liu, Yang Gao, Hongbing Cai   +6 more
wiley   +1 more source

Innovations in Instrumentation for Positron Emission Tomography.

Seminars in nuclear medicine, 2018
PET scanners are sophisticated and highly sensitive biomedical imaging devices that can produce highly quantitative images showing the 3-dimensional distribution of radiotracers inside the body.
E. Berg, S. Cherry
semanticscholar   +1 more source

Positron emission tomography imaging of endometrial cancer using engineered anti-EMP2 antibody fragments. [PDF]

, 2012
PurposeAs imaging of the cell surface tetraspan protein epithelial membrane protein-2 (EMP2) expression in malignant tumors may provide important prognostic and predictive diagnostic information, the goal of this study is to determine if antibody ...
Braun, Jonathan, Brewer, Sarah, Fu, Maoyong, Gordon, Lynn K, Olafsen, Tove, Said, Jonathan, Wadehra, Madhuri, Wu, Anna M   +7 more
core   +3 more sources

Efficiency of quantum state tomography for qubits [PDF]

arXiv, 2010
The efficiency of quantum state tomography is discussed from the point of view of quantum parameter estimation theory, in which the trace of the weighted covariance is to be minimized. It is shown that tomography is optimal only when a special weight is adopted.
arxiv  

Noninvasive Assessment of β‐Secretase Activity Through Click Chemistry‐Mediated Enrichment of Neuronal Extracellular Vesicles to Detect Alzheimer's Disease

Advanced Science, EarlyView.
This study presents the NEV β‐secretase activity assay, a groundbreaking method for noninvasive evaluation of β‐secretase activity in Alzheimer's disease (AD) patients, enabling the generation of individualized β‐secretase activity profiles.
Hyoyong Kim, Junseok Lee, Audrey Qian, You‐Ren Ji, Ryan Zhang, Qixin Hu, Christopher Kazu Williams, Han‐Yu Chuang, Matthew D. Smalley, Yaya Xu, Liang Gao, Mary C. Mayo, Ting Zhang, Edwin M. Posadas, Zaldy S. Tan, Harry V. Vinters, Keith Vossel, Shino Magaki, Yazhen Zhu, Hsian‐Rong Tseng   +19 more
wiley   +1 more source

Identifying active vascular microcalcification by 18F-sodium fluoride positron emission tomography

Nature Communications, 2015
Vascular calcification is a complex biological process that is a hallmark of atherosclerosis. While macrocalcification confers plaque stability, microcalcification is a key feature of high-risk atheroma and is associated with increased morbidity and ...
Agnese Irkle, A. Vesey, David Y. Lewis, J. Skepper, Joseph L. E. Bird, M. Dweck, Francis R. Joshi, Ferdia A. Gallagher, Elizabeth A. Warburton, Martin R. Bennett, Kevin M. Brindle, D. E. Newby, J. Rudd, Anthony P. Davenport   +13 more
semanticscholar   +1 more source

Clinically Valuable Quality Control for PET/MRI Systems: Consensus Recommendation From the HYBRID Consortium

Frontiers in Physics, 2019
Quality control (QC) of medical imaging devices is essential to ensure their proper function and to gain accurate and quantitative results. Therefore, several international bodies have published QC guidelines and recommendations for a wide range of ...
Alejandra Valladares, Sahar Ahangari, Thomas Beyer, Ronald Boellaard, Ronald Boellaard, Zacharias Chalampalakis, Claude Comtat, Laura DalToso, Adam E. Hansen, Michel Koole, Jane Mackewn, Paul Marsden, Johan Nuyts, Francesco Padormo, Ronald Peeters, Sebastian Poth, Esteban Solari, Ivo Rausch   +17 more
doaj   +1 more source