British Journal of Clinical Pharmacology, EarlyView.Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg +7 more
wiley +1 more source
Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics
British Journal of Clinical Pharmacology, EarlyView.Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay +5 more
wiley +1 more source
BMEMat, EarlyView.We developed a cyclo‐RGD peptide‐conjugated antiferromagnetic nanoparticle (RANP) as a targeted T1 contrast agent. Under 9 T MRI conditions, RANP exhibited an r1 value of 1.88 mM−1 s−1 and a low r2/r1 ratio of 1.84, enabling the detection of esophageal tumors as small as 0.8 mm in vivo. Abstract Early, non‐invasive detection of esophageal cancer at sub‐
Wenkui Mo +15 more
wiley +1 more source
Recent Insights Into Alzheimer's Disease: Advances in Pathophysiology and Therapeutic Strategies
Brain Health, EarlyView.ABSTRACT Alzheimer's disease (AD) is a complex neurodegenerative disorder driven by interplay among amyloid‐β (Aβ) plaques, tau neurofibrillary tangles, inflammation and comorbid pathologies. Recent advances in biomarkers and therapeutic approvals have reshaped our understanding of its pathophysiology and treatment landscape.
Jiong Shi +3 more
wiley +1 more source
Contemporary and Emerging Therapies in the Management of Refractory Angina: A Clinical Review
Catheterization and Cardiovascular Interventions, EarlyView.ABSTRACT Refractory angina (RA) represents a growing challenge in clinical cardiology, particularly in patients with obstructive coronary artery disease (CAD) who remain symptomatic despite optimal medical therapy and who are not candidates for revascularization.
Alex Angers‐Goulet +4 more
wiley +1 more source
Development of zirconium-89 chelators for use in positron emission tomography imaging
, 2017 B Jowanaridhi
openalex +1 more source
Pulmonary Cryptococcosis With Rapid Growth on Positron Emission Tomography/Computed Tomography. [PDF]
Respirol Case RepFukuda Y, Oda N, Sagara H, Tanaka A.
europepmc +1 more source
Optimization of CEST MRI Reporter Protein Design Using Cation‐Pi Networks
Chemistry – A European Journal, EarlyView.A novel engineering approach can produce reporter proteins for cell and viral therapy tracking with unique magnetic resonance imaging (MRI) signatures, detectable with chemical exchange saturation transfer (CEST). We discover how cation‐π interactions between amino acid groups can help us fine‐tune magnetic resonance properties for noninvasive ...
David E. Korenchan +8 more
wiley +1 more source
Positron Emission Tomography in Minor Ischemic Stroke Using Oxygen-15 Steady-State Technique [PDF]
, 1987 Carlo Pozzilli +7 more
openalex +1 more source
<sup>18</sup>F-fluorodeoxyglucose positron emission tomography/computed tomography and <sup>18</sup>F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging in lung cancer metastasis after surgery. [PDF]
J Clin Imaging SciPu Y, Zhou K, Huang Y, Chen L.
europepmc +1 more source