Results 41 to 50 of about 271,559 (315)

Fragile X Mental Retardation Protein and Cerebral Expression of Metabotropic Glutamate Receptor Subtype 5 in Men with Fragile X Syndrome: A Pilot Study

Brain Sciences, 2022
Multiple lines of evidence suggest that a deficiency of Fragile X Mental Retardation Protein (FMRP) mediates dysfunction of the metabotropic glutamate receptor subtype 5 (mGluR5) in the pathogenesis of fragile X syndrome (FXS), the most commonly known ...
James Robert Brašić, Jack Alexander Goodman, Ayon Nandi, David S. Russell, Danna Jennings, Olivier Barret, Samuel D. Martin, Keith Slifer, Thomas Sedlak, Anil Kumar Mathur, John P. Seibyl, Elizabeth M. Berry-Kravis, Dean F. Wong, Dejan B. Budimirovic   +13 more
doaj   +1 more source

Association between cognitive performance and cortical glucose metabolism in patients with mild Alzheimer's disease [PDF]

, 2005
Background: Neuronal and synaptic function in Alzheimer's disease (AD) is measured in vivo by glucose metabolism using positron emission tomography (PET). Objective: We hypothesized that neuronal activation as measured by PET is a more sensitive index of
Teipel, S. J., Schwaiger, Markus, Drzezga, A., Hampel, H., Bokde, ALW, Leinsinger, G., Born, C., Thissen, J., Bartenstein, P., Dong, W., Schwaiger, M., Möller, Hans-Jürgen   +11 more
core   +1 more source

Development of an automated method for in-house production of sodium 18F-fluoride for injection: process validation as a step toward routine clinical application

EJNMMI Radiopharmacy and Chemistry
Background Sodium 18F-fluoride for injection can be easily cyclotron-produced and purified, as a simple inorganic salt, by adsorption/desorption onto an anion-exchange cartridge and then dispensed for clinical use.
Marija Atanasova Lazareva, Maja Chochevska, Katerina Kolevska, Maja Velickovska, Filip Jolevski, Paulina Apostolova, Ana Ugrinska, Emilija Janevik-Ivanovska   +7 more
doaj   +1 more source

The Application of PET/CT in Predicting and Evaluating the Therapeutic Response in Chemotherapy of Solid Tumor

Journal of Isotopes, 2017
Three aspects of the application of PET/CT in solid tumor chemotherapy were summarized, including the selection of evaluation criteria, the proper time of using PET/CT in the evaluation and the parameters of PET/CT in evaluating the response of ...
positron emission tomography solid tumor chemotherapy predicton of therapeutic response
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

[11C]-L-Methionine positron emission tomography in the management of children and young adults with brain tumors

, 2009
Only a few Methyl-[11C]-l-methionine (MET) positron emission tomography (PET) studies have focused on children and young adults with brain neoplasm. Due to radiation exposure, long scan acquisition time, and the need for sedation in young children MET ...
Johannes C. Klein, Frank Berthold, Kracht, L., Heiss, Wolf-Dieter, Herholz, Karl; id_orcid, Galldiks, N., Herholz, Karl, Klein, Johannes C., Heiss, Wolf Dieter, Jacobs, Andreas H., Hrvoje Miletic, Heiss, W., Lutz W. Kracht, Wolf-Dieter Heiss, Berthold, Frank, Klein, Johannes Christian, Jacobs, A., Kracht, Lutz W., Karl Herholz, Galldiks, Norbert, Miletic, Hrvoje, Herholz, K., Berthold, F., Norbert Galldiks, Klein, J., Kracht, Lutz Walter, Andreas H. Jacobs, Miletic, H.   +27 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye, Zu‐Ying Kuang, Bo Li, Meng‐Qiu Pan, Li‐Hua Zhou, Yang‐Yang Dai, Si‐Fen Xie, Xian‐Guang Lin, Ye‐Peng Hu, Li‐Hong Jiang, Zhan‐Hang Wang, Wei‐Jing Zhang   +11 more
wiley   +1 more source

Cortical Activity During an Attack of Ménière's Disease—A Case Report

Frontiers in Neurology, 2021
Background: Ménière's disease (MD) is a chronic peripheral vestibular disorder with recurrent episodes of vertigo accompanied by fluctuating hearing loss, tinnitus and aural fullness in the affected ear. There are several unanswered fundamental questions
Louise Devantier, Louise Devantier, Allan K. Hansen, Jens-Jacob Mølby-Henriksen, Michael Pedersen, Michael Pedersen, Per Borghammer, Therese Ovesen, Therese Ovesen, Måns Magnusson   +9 more
doaj   +1 more source

Detectability of colorectal neoplasia with fluorine-18-2-fluoro-2-deoxy-D-glucose positron emission tomography and computed tomography (FDG-PET/CT)

, 2011
The purpose of this study was to analyze the detectability of colorectal neoplasia with fluorine-18-2-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography (FDG-PET/CT). Data for a total of 492 patients who had undergone both PET/CT
Saito, Shunsuke, Sakiko Hiraoka, Tomoko Hirakawa, Kato, Jun, Shunsuke Saito, Hirakawa, Tomoko, Kaji, Eisuke, Higashi, Reiji, Sakuma Takahashi, Mitsuhiro Akita, Hori, Keisuke, Yoshihiro Okumura, Toshio Uraoka, Akita, Mitsuhiro, Kazuhide Yamamoto, Okumura, Yoshihiro, Hiraoka, Sakiko, Jun Kato, Reiji Higashi, Takahashi, Sakuma, Yamamoto, Kazuhide, Eisuke Kaji, Uraoka, Toshio, Keisuke Hori, Suzuki, Hideyuki, Hideyuki Suzuki   +25 more
core   +1 more source