Results 81 to 90 of about 604,820 (405)

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Reduced Expression of Cerebral Metabotropic Glutamate Receptor Subtype 5 in Men with Fragile X Syndrome

Brain Sciences, 2020
Glutamatergic receptor expression is mostly unknown in adults with fragile X syndrome (FXS). Favorable behavioral effects of negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 5 (mGluR5) in fmr1 knockout (KO) mouse ...
James R. Brašić, Ayon Nandi, David S. Russell, Danna Jennings, Olivier Barret, Anil Mathur, Keith Slifer, Thomas Sedlak, Samuel D. Martin, Zabecca Brinson, Pankhuri Vyas, John P. Seibyl, Elizabeth M. Berry-Kravis, Dean F. Wong, Dejan B. Budimirovic   +14 more
doaj   +1 more source

Pre-Operative Prediction of Mediastinal Node Metastasis Using Radiomics Model Based on 18F-FDG PET/CT of the Primary Tumor in Non-Small Cell Lung Cancer Patients

Frontiers in Medicine, 2021
Purpose: We investigated whether a fluorine-18-fluorodeoxy glucose positron emission tomography/computed tomography (18F-FDG PET/CT)-based radiomics model (RM) could predict the pathological mediastinal lymph node staging (pN staging) in patients with ...
Kai Zheng, Kai Zheng, Kai Zheng, Xinrong Wang, Chengzhi Jiang, Yongxiang Tang, Zhihui Fang, Jiale Hou, Zehua Zhu, Shuo Hu, Shuo Hu, Shuo Hu   +11 more
doaj   +1 more source

A statistical reconstruction algorithm for positronium lifetime imaging using time-of-flight positron emission tomography [PDF]

arXiv, 2022
Positron emission tomography (PET) is an important modality for diagnosing diseases such as cancer and Alzheimer's disease, capable of revealing the uptake of radiolabeled molecules that target specific pathological markers of the diseases. Recently, positronium lifetime imaging (PLI) that adds to traditional PET the ability to explore properties of ...
arxiv  

Plastic scintillators for positron emission tomography obtained by the bulk polymerization method [PDF]

Bio-Algorithms and Med-Systems 10(1), 27-31 (2014), 2015
This paper describes three methods regarding the production of plastic scintillators. One method appears to be suitable for the manufacturing of plastic scintillator, revealing properties which fulfill the requirements of novel positron emission tomography scanners based on plastic scintillators.
arxiv   +1 more source

[18F]AV‐1451 tau positron emission tomography in progressive supranuclear palsy

Movement Disorders, 2017
The [18F]AV‐1451 positron emission tomography ligand allows the in vivo assessment of tau proteins in the brain. It shows strong binding in Alzheimer's dementia, but little is known about how it performs in progressive supranuclear palsy, a primary 4R ...
J. Whitwell, V. Lowe, Nirubol Tosakulwong, S. Weigand, M. Senjem, C. Schwarz, Anthony J. Spychalla, R. Petersen, C. Jack, K. Josephs   +9 more
semanticscholar   +1 more source

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

Molecular Oncology, EarlyView.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam, Salem Chouaib, Mohammad Askandar Iqbal   +2 more
wiley   +1 more source

Lymph node metastasis of squamous cell carcinoma from an unknown primary in the upper and middle neck: impact of 18F-fluorodeoxyglucose positron emission tomography/computed tomography [PDF]

, 2011
Purpose: The purpose of this study was to assess the potential of F-18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) imaging for detection of the primary tumor and its impact on treatment planning in patients presenting
Bonte, Katrien, Deron, Philippe, Van De Wiele, Christophe, Vermeersch, Hubert   +3 more
core   +1 more source

Derisking the Cu-Mediated 18F-Fluorination of Heterocyclic Positron Emission Tomography Radioligands.

Journal of the American Chemical Society, 2017
Molecules labeled with fluorine-18 (18F) are used in positron emission tomography to visualize, characterize and measure biological processes in the body.
N. Taylor, E. Emer, Sean M. Preshlock, M. Schedler, M. Tredwell, Stefan Verhoog, J. Mercier, C. Genicot, V. Gouverneur   +8 more
semanticscholar   +1 more source

Cardiac Positron Emission Tomography

Journal of the American College of Cardiology, 2009
Positron emission tomography (PET) is a powerful, quantitative imaging modality that has been used for decades to noninvasively investigate cardiovascular biology and physiology. Due to limited availability, methodologic complexity, and high costs, it has long been seen as a research tool and as a reference method for validation of other diagnostic ...
Frank M. Bengel, Riikka Lautamäki, Takahiro Higuchi, Mehrbod S. Javadi   +3 more
openaire   +3 more sources