Results 91 to 100 of about 8,903 (303)

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Delokutivität, Possessive und die italienischen Verwandtschaftsbezeichnungen

Linguistik Online, 2003
This contribution is about a hitherto unexplained phenomenon of Italian syntax, i.e. the lack of a determiner in nominal expressions of a certain type that contain a possessive and a kinship noun as its scope, despite the fact that possessives normally ...
Klaus Hölker
doaj   +1 more source

Adposition and Case Supersenses v2.5: Guidelines for English

, 2020
This document offers a detailed linguistic description of SNACS (Semantic Network of Adposition and Case Supersenses; Schneider et al., 2018), an inventory of 50 semantic labels ("supersenses") that characterize the use of adpositions and case markers at
Abend, Omri, Bhatia, Archna, Blodgett, Austin, Han, Na-Rae, Hwang, Jena D., Moeller, Sarah R., O'Gorman, Tim, Prange, Jakob, Schneider, Nathan, Shalev, Adi, Srikumar, Vivek   +10 more
core  

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Corpus Linguistics based error analysis of first year Universiti Teknologi Malaysia students’ writing [PDF]

, 2010
The ability to write in English among Malaysian university students is generally not at the most satisfactory level although English is considered as a second language. There has been a growing research interest in the analysis of errors students make in
Mahady, Nurul Ros Adira, Shamsudin, Sarimah   +1 more
core  

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Children's acquisition of recursive possessives in Mandarin

Journal of Child Language Acquisition and Development
This study investigates the developmental stages in the acquisition of two-level possessive recursive structures by Mandarin-speaking children aged 3 to 6. Using the 'answering a question while seeing a picture' task, it was found that children begin to
Fu Chenxi, Wang Xiaoyi, Zhuang Ziman, Yang Caimei   +3 more
doaj   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Alignment optimality and English possessives: Knowing where to stop [PDF]

Bucharest Working Papers in Linguistics, 2017
The present paper argues that an Optimality Theoretic framework may better handle the order of appearance of elements inside what is traditionally termed a possessive NP in English than approaches embedded in X-bar Theory.
Marianna Hordós
doaj