Results 121 to 130 of about 7,117,019 (296)

Numerical methods for analysis of mechanical systems with uncertain parameters

open access: yesProduction Engineering Archives, 2016
The paper presents new and improved numerical methods designed for analysis of mechanical systems with uncertain parameters. Uncertain parameters in mechanical systems are described by means of possibility theory. The main representatives of this theory
Milan Vaško, Milan Sága, Alan Vaško
doaj  

Administração pública tupiniquim: reflexões a partir da Teoria N e da Teoria P de Guerreiro Ramos

open access: yesCadernos EBAPE.BR
O objetivo deste ensaio teórico é promover uma reflexão acerca da administração pública brasileira contemporânea sob o enfoque da Teoria N e da Teoria P de Guerreiro Ramos.
Elisa Zwick   +3 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

Possibility Theory: Qualitative and Quantitative Aspects

open access: yes, 1998
International audienceIn recent years there has been a major trend in uncertainty (more specifically, partial belief) modelling emphasizing the idea that the degree of confidence in an event is not totally determined by the confidence in the opposite ...
Prade, Henri   +3 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

Possibility Theory, Probability Theory and Multiple-Valued Logics: A Clarification

open access: yes, 2001
International audienceThere has been a long-lasting misunderstanding in the literature of artificial intelligence and uncertainty modeling, regarding the role of fuzzy set theory and many-valued logics.
Didier Dubois, Dubois, Didier
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

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