Results 101 to 110 of about 7,117,019 (296)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Qualitative Model-Based Diagnosis Using Possibility Theory [PDF]

, 1994
The potential for the use of possibility theory in the qualitative model-based diagnosis of spacecraft systems is described. The first sections of the paper briefly introduce the Model-Based Diagnostic (mbd) approach to spacecraft fault diagnosis ...
Joslyn, Cliff, Cliff Joslyn
core  

An Extended Epistemic Framework Beyond Probability for Quantum Information Processing with Applications in Security, Artificial Intelligence, and Financial Computing

Entropy
In this work, we propose a novel quantum-informed epistemic framework that extends the classical notion of probability by integrating plausibility, credibility, and possibility as distinct yet complementary measures of uncertainty.
Gerardo Iovane
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Data clustering based on possibility theory [PDF]

, 2013
У роботі розглянуто підхід до кластеризації, що базується на теорії можливостей. Такий підхід дозволяє врахувати неоднозначність вибору параметрів алгоритму кластеризації.
Касьянюк, Веда, Малютенко, Людмила   +1 more
core  

Possibility theory, 3: possibilistic independence

, 1997
The introduction of the notion of independence in possibility theory is a problem of long-standing interest. Many of the measure-theoretic definitions that have up to now been given in the literature face some difficulties as far as interpretation is ...
de Cooman, Gert
core   +1 more source

The Efficiency Evaluation of DEA Model Incorporating Improved Possibility Theory

Mathematics
The data envelopment analysis (DEA) models have been widely recognized and applied in various fields. However, these models have limitations, such as their inability to globally rank DMUs, the efficiency values are definite numerical values, they are ...
Shenzi Yang, Guoqing Zhao, Fan Li
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Estimation of Reservoir Storage Capacity Using the Gould-Dincer Formula with the Aid of Possibility Theory

Hydrology
This paper presents a method for estimating reservoir storage capacity using the Gould–Dincer normal formula (G-DN), enhanced by the possibility theory.
Nikos Mylonas, Christos Tzimopoulos, Basil Papadopoulos, Nikiforos Samarinas   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source