Results 81 to 90 of about 3,465,090 (288)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Information compression in the context model [PDF]
The Context Model provides a formal framework for the representation, interpretation, and analysis of vague and uncertain data. The clear semantics of the underlying concepts make it feasible to compare well-known approaches to the modeling of imperfect ...
Gebhardt, Joerg +2 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Wavefront Propagation and Fuzzy Based Autonomous Navigation
International Journal of Advanced Robotic Systems, 2008 Path planning and obstacle avoidance are the two major issues in any navigation system. Wavefront propagation algorithm, as a good path planner, can be used to determine an optimal path.
Cindy Leung, Adel Al-Jumaily
doaj
CAAI Transactions on Intelligence Technology, 2019 This study presented a multi-objective linear fractional inventory (LFI) problem with generalised intuitionistic fuzzy numbers. In modelling, the authors have assumed the ambiances where generalised trapezoidal intuitionistic fuzzy numbers (GTIFNs) used ...
Totan Garai, Harish Garg
doaj +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Sensors, 2012 This study proposes a new condition diagnosis method for rotating machinery developed using least squares mapping (LSM) and a fuzzy neural network. The non-dimensional symptom parameters (NSPs) in the time domain are defined to reflect the features of ...
Peng Chen, Shiming Wang, Ke Li
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
About Possible Extensions of Quantum Theory
Foundations of Physics, 2013 Recently it has been claimed that no extension of quantum theory can have improved predictive power, the statement following, according to the authors, from the assumptions of free will and of the correctness of quantum predictions concerning the correlations of measurement outcomes. Here we prove that the argument is basically awed by an inappropriate
Ghirardi, GianCarlo, Romano, Raffaele
openaire +2 more sources