Results 121 to 130 of about 16,273 (298)
Advanced Science, EarlyView.This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi +16 more
wiley +1 more source
Geography, population density, and per-capita income gaps across US states and Canadian provinces [PDF]
We explain per-capita income gaps across US states and Canadian provinces by the following chain of causation. Geography determined where Europeans originally settled: in Northeastern USA, along those segments of the Atlantic coast where the climate was ...
Basher, Syed A., Lagerlöf, Nils-Petter
core +1 more source
Advanced Science, EarlyView.ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao +11 more
wiley +1 more source
Advanced Science, EarlyView.DOT1L as a central epigenetic regulator of EndoMT and pulmonary fibrosis. Acting as an early epigenetic switch, it translates TGFβ–SMAD signaling into H3K79me2‐mediated chromatin remodeling, selectively activates fibrosis‐related genes, and primes ECs for rapid mesenchymal transition.
Yaofeng Wang +11 more
wiley +1 more source
Slavery and codification in brazil, 1888-2017: for a decolonized history of latin american law [PDF]
, 2018 Brasil cuenta hoy con Constitución, Código Civil y Código Penal cimentados todos en derechos de libertad sin resquicio pensable para la esclavitud. El Código Civil, código que abarca al derecho mercantil, se inspira en un constitucionalismo social que no
Clavero Salvador, Bartolomé
core
Infant birth weight in Brazil: A cross-sectional historical approach [PDF]
In 1888, Brazil became the last country in the Americas to abolish slavery. Historians have outlined the racialized health disparities of people of African descent in the post-abolition period.
Roth, Cassia
core +1 more source
Embedded CRISPRi Enhances Gene‐Silencing Efficiency in Drosophila
Advanced Science, EarlyView.Current CRISPR interference (CRISPRi) technology in Drosophila has limited efficiency. This study introduces the emCRISPRi platform, which significantly enhances transcriptional silencing efficacy by embedding inhibitory domains within the dCas9 architecture.
Pengchong Fu +7 more
wiley +1 more source
Forecasting migration between the EU, V4 and Eastern Europe. Impact of visa abolition. OSW Report, July 2014 [PDF]
, 2014 This book is the result of one year of solid work among a multinational research team assembled from seven states (Poland, Czechia, Hungary, Slovakia, Ukraine, Belarus and Moldova).
Benč, Vladimír +12 more
core
Halofuginone is a Molecular Glue Degrader of Integrin β4
Advanced Science, EarlyView.Integrin β4 overexpression is linked to aggressive tumors and poor prognosis, but targeted therapies are lacking. We identified halofuginone (HF) as a molecular glue degrader that promotes integrin β4 degradation via the CRL4BWDR18 E3 ligase. HF suppresses tumor progression in vitro and in vivo, offering a new strategy for targeting oncogenic ...
Wei Gong +8 more
wiley +1 more source