Results 131 to 140 of about 16,273 (298)

Black Women: A Trajectory of Creativity, Determination and Organization

Revista Estudos Feministas, 2008
The article “Black Women: A Trajectory of Creativity, Determination and Organization” seeks to make a brief account, focusing on the process of black women’s organization in dialogue with the following: the inclusion of gender and race in public ...
Matilde Ribeiro
doaj  

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

Slave Legacies, Ambivalent Modernity: Street Commerce and the Transition to Free Labor in Rio de Janeiro, 1850-1925 [PDF]

, 2010
"Slave Legacies, Ambivalent Modernity: Street Commerce and the Transition to Free Labor in Rio de Janeiro, 1850-1925" is a history of street vending during the transition from enslaved to free labor in the capital of the most enduring slave society of ...
Acerbi, Patricia
core  

Single‐Cell Transcriptomics Reveals FLS2‐Dependent Hypoxia Signaling and ERF13‐Mediated Transcription During flg22‐Triggered Immunity

Advanced Science, EarlyView.
This study employs sc‐RNA sequencing, genetics, and phenotyping to systematically map the cell‐type‐specific immune responses triggered by flg22. It reveals FLS2‐dependent transcriptional reprogramming in epidermal and mesophyll cells, and uncovers crosstalk between immune and hypoxia signaling pathways.
Yaping Zhou, Aizhi Qin, Mengfan Li, Qianli Zhao, Luyao Kong, Lulu Yan, Chunyang Li, Hao Liu, Yinpeng Zhang, Jiani Long, Mengyu Liao, Mengmeng Zhou, Xiaoli Fan, Baozhen Wang, Wenxuan Kang, Shui Wang, Zhixin Liu, Xuwu Sun   +17 more
wiley   +1 more source

Colonialisms, post-colonialisms and lusophonies: proceedings of the 4th International Congress in Cultural Studies [PDF]

, 2014
Colonialismos e pós-colonialismos são todos diferentes, mesmo quando referidos exclusivamente à situação lusófona. Neste contexto, mais do que procurar boas respostas, importa determinar quais as questões pertinentes aos nossos colonialismos e pós ...
Baptista, Maria Manuel, International Congress in Cultural Studies, 4, Aveiro, 2014, Maia, Sara Vidal   +2 more
core  

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Instruction, labor and family in the post-abolition in Santa Maria/RS (1930’s)

Revista Aedos, 2023
Esta pesquisa busca refletir sobre o perfil social e racial do alunado presente no espaço educacional da Escola Elementar Olavo Bilac, localizado em Santa Maria/RS, nos anos de 1937 e 1938. A construção da análise sobre os perfis de estudantes se deu através do levantamento quantitativo e serial de cerca de 1.300 matrículas escolares, salvaguardadas no
openaire   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Slave-Trade, Christianity and European Imperialism In Nigeria: A Study of the Ante and Post Abolition Periods [PDF]

, 2014
The approval of Christian founding fathers for African enslavement may be the slave -trade and their active involvement in the trade has vast literatures. They were as beneficiaries of the trade and slave institutions as nations of Europe.
Anaele, Cyril
core   +1 more source