Results 151 to 160 of about 16,273 (298)

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

Too Black for Care: Clinical Apperception, Anti-Blackness, and Narrative Aporia. [PDF]

Cult Med Psychiatry
Cherian R.
europepmc   +1 more source

Review of \u3cem\u3eThe Women\u27s War of 1929: Gender and Violence in Colonial Nigeria\u3c/em\u3e [PDF]

, 2015
Korieh, Chima J.
core   +1 more source

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

BADGAGE AND THE NEW FORMS OF CONTROL OF THE URBAN POST-ABOLITION BLACK POPULATION.

, 2019
O presente artigo tem como objetivo discutir acerca do controle da população negra brasileira, egressa do sistema escravocrata, nos centros urbanos nos anos subsequentes ao término da escravidão e início da República Velha. Através de pesquisa bibliográfica traçaremos considerações acerca das penalizações previstas pelo tipo penal enquadrado na ...
Paulino, Silvia Campos, Oliveira, Rosane
openaire   +1 more source

The AUTACE That Degrades KRAS and Engages CD8+ T Cells for the Treatment of KRAS/TP53 Co‐Mutant Tumors

Advanced Science, EarlyView.
AUTACE is a bifunctional nanoplatform that integrates tumor targeting, immune engagement, and on‐demand KRAS degradation. It targets KRAS/TP53 co‐mutant tumors via TP53‐specific TCRs, elicits antitumor CD8+ T‐cell responses through surface anti‐CD3 antibodies, and uses low‐intensity focused ultrasound (LIFU) to trigger controlled release of the KRAS ...
Luo Li, Bolin Li, Yanan Hao, Bo Pang, Pan Li, Chunli Li, Yu Tang   +6 more
wiley   +1 more source

Overdose Effects of Medetomidine and Fentanyl in Rats: Reflex, Vital and Analgesic Parameters as Predictive Markers. [PDF]

Vet Med (Auckl)
Zalischi DB, Cătană L, Ştefănuţ LC, Popescu A, Iozon I, Muntean A, Cernea M.   +6 more
europepmc   +1 more source

Context‐Dependent Role of GDF15: GDF15+ Tumor‐Associated Macrophages Suppress OSCC Progression by Enhancing Phagocytosis

Advanced Science, EarlyView.
This study identifies GDF15+ TAMs as a cell subset mediating tumor regression after immunotherapy. Macrophage‐intrinsic GDF15 enhances phagocytosis and antigen cross‐presentation to CD8+ T cells through the NF‐κB signaling pathway, thereby inhibiting tumor progression.
Xinyu Zhou, Zhihang Zhou, Houyu Ju, Chaoyang Guo, Fangxing Zhu, Yiyi Zhang, Xu Chen, Tongchao Zhao, Laiping Zhong, Jingzhou Hu   +9 more
wiley   +1 more source

Transcatheter Occlusion of Hepatic Vein-Atrial Communication After Modified Fontan in a Child Post Kawashima Surgery. [PDF]

JACC Case Rep
Rajan S, Sundaram A, Coelho R.
europepmc   +1 more source

Latitudes of Indenture: Portuguese Islanders in Post-Abolition Guiana Plantations and in Hawai‘i

In this article, one can bring together two different societies in which Madeiran islanders became a distinct local group after migrating there as contract labourers: British Guyana and Hawai‘i. Both societies rested on a labour-devouring sugar economy that, at different moments, made use of contingents of Portuguese islanders from Madeira and, to a ...
openaire   +2 more sources