Results 111 to 120 of about 7,159,145 (282)

Annual report, fiscal year 1988 : follow-up report on audit recommendations.

, 1988
"A Report to the Kansas Legislature by the Legislative Post Audit Committee, state of Kansas."; Fiscal year ends June 30.Constitutes the annual report of the ...
Kansas. Legislative Post Audit Committee.
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Microbial Communities Associated with Post-Byzantine Icons: A Multi-Analytical Study

Heritage
Post-Byzantine portable icons are complex, multilayered heritage objects whose preservation may be influenced by interactions among their constituent materials, environmental conditions, and associated microorganisms.
Styliani Permathouli, Dimitrios Karakalpakidis, Nikolaos Skiathitis, Maria Anastasiou, Antonios-Dionisios Petrakis, Michalis Paraskeva, Maria V. Alvanou, Ioannis Karakasiliotis, Lamprini Malletzidou, Christine Kottaridi   +9 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Promoting analytical thinking skills development in elementary school students through animated cartoons

Computers in Human Behavior Reports
Traditional educational settings often struggle to engage students and cater to their individual needs when cultivating analytical thinking skills. This study addresses this challenge by exploring the potential of animated cartoons to enhance analytical ...
Parama Kwangmuang, Suwisa Jarutkamolpong, Pornpisut Duangngern, Nantapoom Gessala, Paritchaya Sarakan   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

OPTIMIZATION OF GAS-CHROMATOGRAPHIC ANALYTICAL METHODS FOR TOXIC COMPOUNDS IN AIR

, 1994
This is a review article concernning the development of a gas chromatographic analytical method for the analysis of 70 air toxic compounds. Not only the operating conditions, but also the column system is optimized.
LU, PC, LI, Y, ZHANG, XM, XU, GW, ZHANG, YK   +4 more
core  

Analytical errors in the laboratory of a general hospital of the Thai Red Cross Society: A 3-year experience

Journal of Associated Medical Sciences
Background:Laboratory test results are critical to clinical decision-making, including patient screening, diagnosis, treatment planning, and monitoring therapeutic responses. Therefore, laboratory errors can significantly impact patient care and outcomes.
Srivilai Trakulkaseamsiri, Kittipong Chumchujan   +1 more
doaj   +1 more source