Results 141 to 150 of about 5,534,109 (312)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Cocaleros. Violence, Drugs and Social Mobilization in the Post-Conflict Upper Huallaga Valley, Peru

, 2009
During Peru’s internal armed conflict (1980s-1990s) the Upper Huallaga Valley became one of the most violent theaters of conflict, with political violence and violent crime becoming causally related phenomena.
Political Conflict, Cultural Trauma and Social Reconstruction, Afd culturele antropologie, van Dun, M.E.H.   +2 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Emergency care in post-conflict settings: a systematic literature review. [PDF]

BMC Emerg Med, 2023
Werner K, Kak M, Herbst CH, Lin TK.
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Adolescent mental health in post-conflict communities: results from a cross-sectional survey in Northern Uganda. [PDF]

Confl Health, 2023
Wipfli H, Guy K, Kim A, Tumuhimbise P, Odur K, Lira Youth Public Health Ambassadors.   +5 more
europepmc   +2 more sources

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

"Economic Aid to Post-conflict Countries: A Methodological Critique of Collier and Hoeffler" [PDF]

This paper retests the analysis of "Aid Policy and Growth in Post-Conflict Societies," by Paul Collier and Anke Hoeffler (October 2002 and forthcoming in European Economic Review).
Astri Suhrke, Espen Villanger, Susan L. Woodward   +2 more
core  

From Rebels to Rulers and Legislators: The Political Transformation of the Free Aceh Movement (GAM) in Indonesia

Journal of Current Southeast Asian Affairs, 2010
On 15 August 2005, when the Republic of Indonesia and the Free Aceh Movement (Gerakan Aceh Merdeka, GAM) signed the Memorandum of Understanding (MoU) in Helsinki, Finland, it was considered yet another uncertain attempt at putting an end to Indonesia’s ...
Gunnar Stange, Roman Patock
doaj  

Post-conflict acute stress reactions in Kazakhstan in the aftermath of January 2022 unrests: A national survey. [PDF]

Heliyon, 2023
Glushkova N, Ivankov A, Trenina V, Oshibayeva A, Kalmatayeva Z, Temirbekova Z, Mamyrbekova S, Davletov K, Khismetova Z, Kauysheva A, Auyezova A, Zhanaspayev M, Pivina L, Koshmaganbetova G, Nurbakyt A, Sarsenbayeva G, Sadibekova Z, Gazaliyeva M, Kulimbet M, Kalmatayeva D, Zhylkybekova A, Nurgaliyeva Z, Sultanbekov K, Semenov D, Izmailovich M, Tsigengagel O, Munir K.   +26 more
europepmc   +1 more source