Results 61 to 70 of about 5,534,109 (312)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Rethinking neo-liberal state building: building post-conflict development states
, 2008 In attempting to rebuild post-conflict failed states, the international community has drawn heavily on neo-liberal development paradigms. However, neo-liberal state building has proved ineffectual in stimulating economic development in post-conflict ...
Barbara, Julien
core +1 more source
Receiving post-conflict affiliation from the enemy's friend reconciles former opponents [PDF]
, 2010 The adaptive function of bystander initiated post-conflict affiliation (also: consolation & appeasement) has been debated for 30 years. Three influential hypotheses compete for the most likely explanation but have not previously been tested with a single
Roman M Wittig +9 more
core +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
The investment climate in post-conflict situations [PDF]
This paper is a policy review of the role of investment climate in post-conflict situations. It summarizes the broad range of ways in which conflict negatively affects the investment climate, from macroeconomic instability to a degraded regulatory ...
Mills, Rob, Qimiao Fan
core
Géographie et Cultures, 2018 This article investigates the concept of ghost places as a tool for understanding the post-conflict situation in Lebanon. The reflection carried out relies on two field studies: Beirut’s nightscape and memory sites in Southern Lebanon. These spaces have
Marie Bonte, Zara Fournier
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Oligopolies of Violence in Post-Conflict Societies [PDF]
In post-conflict societies, security is provided by a broad range of actors including the state as well as various non-state formations. The paper identifies three types of post-conflict societies and analyses dynamics of the security market in cases ...
Daniel Lambach
core
Post-Conflict Land Administration, Facilitator of Post-Conflict State Building
FIG Peer Review Journal, 2016 Land and its administration are always negatively affected during conflicts and in post-conflict contexts. This has been confirmed both in the literature and in practice. This research has shown that if land and its administration are neglected or not properly addressed after the end of a conflict, they can be a cause for a renewed armed conflict and ...
Todorovski, Dimo +2 more
openaire +1 more source