Results 81 to 90 of about 7,211,581 (244)

Youth in post-conflict reconstruction: agents of change

, 2010
In Youth and Post-Conflict Reconstruction: Agents of Change, Stephanie Schwartz goes beyond these highly publicized cases and examines the roles of the broader youth population in post-conflict scenarios, taking on the complex task of distinguishing ...
Schwartz, Stephanie
core   +5 more sources

Post-Conflict Peace Construction in Somaliland

Journal of Central and Eastern European African Studies
The Horn of African region has witnessed a prolonged conflict, and Somaliland has grabbed its share. This article explores and finds answers for the questions related with the blockage factors of post-conflict peace construction in Somaliland, analyses ...
Abdalgani Almi
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Does fiscal policy differ between successful and unsuccessful post-conflict transitions? Lessons from African Civil Wars [PDF]

Purpose- The chapter studies the impact of fiscal policy on the stabilization of peace in the aftermath of a civil war. Methodology- We use data from African war-torn countries and study the issue of post-conflict stabilization from an empirical ...
Fabrizio Carmignani, Adrian Gauci
core  

The role of self-perception in mental health: current insights on self-esteem and self-schemas

Frontiers in Psychiatry
BackgroundSelf perception includes both self-esteem and self-schema and is an important factor in determining an individual's mental health. This is particularly true in contexts that have been affected by war or conflict, such as post-conflict Mosul ...
Radhwan Hussein Ibrahim, Mariwan Qadir Hamarash, Abdulhakeem Jamil Ahmed, Salwa Hazim Al Mukhtar, Marghoob Hussein Yaas   +4 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Health Reform in Post Conflict Kosovo [PDF]

The international community undertakes complex interventions in states emerging from war. These interventions include broad efforts to reform the political and institutional structures of the state.
Percival, Valerie
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

“Before, I only knew how to shout. Now I know how to listen”: A national model for community-based child and caregiver mental health and psychosocial support in Syria

International Review of the Red Cross
Over a decade of conflict has ruptured protective layers for children, adolescents and caregivers in Syria, resulting in heightened mental health and psychosocial support (MHPSS) needs.
Jihad Taha, Lana Feras Aldos, Johanna Cunningham, Lubabah AlMulki, Malvikha Manoj   +4 more
doaj   +1 more source