Results 101 to 110 of about 5,534,109 (312)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
The political economy of resistance in post-conflict South Sudan
, 2015 Despite recent scholarly attention, the phenomenon of resistance in post-conflict environments remains largely under-conceptualized. This represents a major shortcoming in the theory and praxis of post-conflict peacebuilding and development.
Young, Graeme
core
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Post conflict housing reconstruction plays an important role in establishing the country’s development and prospect of peace. Despite this importance, it was identified that there are inconsistencies between the provision of built housing and the needs
Amaratunga, Dilanthi +2 more
core
, 2012 Includes abstract.In times of war the private sector adapts, often to function informally, and can serve to either perpetuate conflict or to incentivize peace.
Walker, Jessica Ayana
core
Public finance, aid and post-conflict recovery [PDF]
In the wake of violent conflict, a key element of building a durable peace is building a state with the ability to collect and manage public resources. To implement peace accords and provide public services, the government must be able to collect revenue,
James K. Boyce
core +2 more sources
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Introduction: ‘Moving On’? Official Responses to Mass Harm and the Question of Justice
Oñati Socio-Legal Series, 2017 How are claims to justice formulated, invoked and confronted in relation to reports of mass human suffering? What notions of justice inform the scope and nature of official inquiries into harms and the responsiveness of governments to their findings and ...
Jennifer Balint +3 more
doaj
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source