Results 281 to 290 of about 326,396 (335)

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, EarlyView.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source

Neurological and Immunological Insights Into Post-COVID-19 Syndrome: A Single-Center Retrospective Study. [PDF]

Cureus
Diem L, Daepp S, Introcaso VP, Hammer H, Friedli C, Kamber N, Chan A, Salmen A, Hoepner R.   +8 more
europepmc   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Cardio-Respiratory Fitness and Fatigue in Post-COVID-19 Syndrome-A Three-Year Update. [PDF]

Biomedicines
Cherneva R, Cherneva Z, Youroukova V, Kadiyska T, Valev D, Hayrula-Manaf EM, Mitev V.   +6 more
europepmc   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Choroid Plexus Enlargement in Post-COVID-19 Syndrome Is Linked to Serum-Induced Cytokine Secretion in Human Hippocampal Progenitors

Martins D, Mariani N, Schubert J, Eiff B, Rota S, Nicholson T, Hampshire A, Veronese M, Williams S, Mondelli V, Pariante C, Borsini A, Turkheimer F.   +12 more
europepmc   +1 more source

Effects of inspiratory muscle training on exercise capacity, muscle oxygenation and strength, physical activity, and dyspnea in patients with post-COVID-19 syndrome and pulmonary involvement: a randomized controlled triple-blinded study. [PDF]

BMC Pulm Med
Kavalcı Kol B, Boşnak Güçlü M, Baytok E, Yılmaz Demirci N.   +3 more
europepmc   +1 more source

Haemostatic changes and bleeding with anti‐IL‐6 directed therapy in autoimmune diseases

British Journal of Pharmacology, EarlyView.
Abstract Anti‐IL‐6 directed therapy, especially tocilizumab (TCZ), is widely used for the treatment of autoimmune diseases such as rheumatoid arthritis, giant cell arteritis and systemic juvenile idiopathic arthritis. Next to being a master regulator of inflammation, IL‐6 also is an important regulator of haemostasis. Although generally well tolerated,
Charlotte D. C. C. van der Heijden, Loes C. Oskam, Lenny van Bon, Chantal P. Rovers   +3 more
wiley   +1 more source

Methodological Evolution of Syndromic Surveillance Systems in the Post–COVID-19 Pandemic: A Systematic Review (Preprint)

Jeong Min Yang, Sojin An, Ji Su Yun, Dong Hyun Kim, Ho Kyung Sung, Kyung-shin Lee, Seonji Kim   +6 more
openalex   +1 more source

Drivers of bat researchers’ intent to adopt field hygiene practices

Conservation Biology, EarlyView.
Abstract Infectious disease is a growing threat to wildlife, with zoonotic transmission most likely at the human–wildlife interface. One underappreciated activity at this interface is fieldwork with wild animals, but associated risks can be mitigated through field hygiene (FH) practices, such as using personal protective equipment and other appropriate
Joanna L. Coleman, Ewan A. Macdonald, Abigail L. Rutrough, Tanja M. Straka, Todd D. Little, Zachary Stickley, Tigga Kingston   +6 more
wiley   +1 more source