Results 271 to 280 of about 631,638 (309)

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, EarlyView.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Anti-neuronal and anti-mitochondrial autoantibodies are associated with lower functional status and more severe respiratory symptoms in post COVID syndrome. [PDF]

Front Immunol
Vogelgesang A, Steinmetz A, Stufano A, Schino V, Plantone D, Flöel A, Lucchese G.   +6 more
europepmc   +1 more source

Top Managerial Network Relations for Knowledge Transfer: Exploring Gender Differences

Creativity and Innovation Management, EarlyView.
ABSTRACT In the ongoing debate surrounding the gender gap in top managerial positions, various possible causes have been explored, with different networking patterns being one of them. However, we still lack detailed insights on how knowledge transfer via networks varies based on gender.
Sonja Sperber, Christian Linder
wiley   +1 more source

Tafasitamab as Monotherapy or in Combination in Japanese Patients With B‐Cell Non‐Hodgkin Lymphoma: Results From the Phase 1b J‐MIND Study

Cancer Science, EarlyView.
J‐MIND evaluated the safety and tolerability of tafasitamab, a CD19‐targeting monoclonal antibody, alone or in combination with other therapies in Japanese patients with B‐cell non‐Hodgkin lymphoma (NHL). Most common treatment‐emergent adverse events across all groups were hematological, and no serious tafasitamab treatment‐related or fatal adverse ...
Koji Izutsu, Noriko Fukuhara, Junichiro Yuda, Youko Suehiro, Shigeru Kusumoto, Marie‐Laure Casadebaig, Kazumi Suzukawa, Kentaro Fukushima   +7 more
wiley   +1 more source

Circadian rhythm disruption and melatonin dysregulation as overlooked drivers of immune imbalance and multiorgan failure in post-COVID syndrome: a call for chronotherapy-based interventions. [PDF]

Ann Med Surg (Lond)
Rizvi GS, Ullah R, Khalid M, Talha M, Waafira A.   +4 more
europepmc   +1 more source

Drivers of bat researchers’ intent to adopt field hygiene practices

Conservation Biology, EarlyView.
Abstract Infectious disease is a growing threat to wildlife, with zoonotic transmission most likely at the human–wildlife interface. One underappreciated activity at this interface is fieldwork with wild animals, but associated risks can be mitigated through field hygiene (FH) practices, such as using personal protective equipment and other appropriate
Joanna L. Coleman, Ewan A. Macdonald, Abigail L. Rutrough, Tanja M. Straka, Todd D. Little, Zachary Stickley, Tigga Kingston   +6 more
wiley   +1 more source

Childhood trauma and mental health outcomes in Post-COVID Syndrome: Results from a cross-sectional study in Germany. [PDF]

Brain Behav Immun Health
Stölting A, Schröder D, Schmachtenberg T, Schimansky I, Yaqubi-Naqizadah M, Klemann C, Rebmann F, Mikuteit M, Steffens S, Behrens GMN, Klawonn F, Dopfer-Jablonka A, Müller F, Happle C.   +13 more
europepmc   +1 more source

Ethical and Regulatory Considerations in the Clinical Translation of Pluripotent Stem Cell‐Derived NK Cell Therapies

Cell Proliferation, EarlyView.
Advancements in the generation of human pluripotent stem cell‐derived natural killer (PSC‐NK) cells have attracted considerable attention within the biomedical research community, offering a promising off‐the‐shelf technique for universal immune therapy.
Qianwen Chen, Jianwei Lv, Xinwei Xie, Hanlin Zhu, Zhenyu Xiao, Yaojin Peng   +5 more
wiley   +1 more source

Impact of QazVac vaccination on clinical manifestations and immune responses in post-COVID syndrome: a cross-sectional study. [PDF]

Front Med (Lausanne)
Madenbayeva AM, Kurmangaliyeva SS, Urazayeva ST, Kurmangaliyev KB, Bazargaliyev YS, Kudabayeva KI.   +5 more
europepmc   +1 more source

Cutaneous and non‐cutaneous diseases due to Mycoplasma pneumoniae in children

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Mycoplasma pneumoniae (MP) is a common pathogen responsible for diverse infections in children and adolescents, primarily affecting the respiratory tract. Besides causing atypical pneumonia, MP can also lead to extrapulmonary manifestations, including mucocutaneous, hematological, neurological, cardiac, and gastrointestinal symptoms.
Hanna Lindemann, Maximilian David Mauritz, Victoria Rehmann, Michael Paulussen, Jorge Frank, Malik Aydin   +5 more
wiley   +1 more source