Results 81 to 90 of about 6,139,878 (265)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

An empirical investigation of cognitive effort required to post-edit machine translated metaphors compared to the translation of metaphors

Translation and Interpreting : the International Journal of Translation and Interpreting Research, 2015
This paper reports on a study investigating cognitive effort required to post-edit machine translated metaphors in comparison to translating metaphors by means of eye tracking and key logging.
Arlene Koglin
doaj  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Machine Translation Post-editing and Effort : Empirical Studies on the Post-editing Process [PDF]

, 2016
This dissertation investigates the practice of machine translation post-editing and the various aspects of effort involved in post-editing work. Through analyses of edits made by post-editors, the work described here examines three main questions: 1 ...
Koponen, Maarit
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Perception vs Reality: Measuring Machine Translation Post-Editing Productivity

, 2014
This paper presents a study of user-perceived vs real machine translation (MT) post-editing effort and productivity gains, focusing on two bidirectional language pairs: English— German and English—Dutch.
Gaspari F, Declan Groves, Antonio Toral, Sudip Kumar Naskar, Andy Way   +4 more
core  

Post-editing beyond error repair: Cultural agency in Arabic-English MT mediation

Social Sciences and Humanities Open
Much research on machine translation post-editing (MTPE) has focused on productivity, cognitive effort and error reduction. Comparatively less attention has been paid to the culturally and pragmatically consequential textual interventions that remain ...
Noureldin Abdelaal, Mariam Alblooshi, Shaikah Al Dhaheri   +2 more
doaj   +1 more source

Cognitive Effort and Perceptions in Translation Revision and Post-Editing

International Journal of Linguistics, Literature and Translation
This study investigates the correlation between cognitive effort and translator perceptions during human translation (HT) revision and machine translation (MT) post-editing. Seven participants revised and post-edited two texts without knowing whether the texts had been produced by a human or a machine.
openaire   +2 more sources