Results 51 to 60 of about 420,049 (252)

Exploring the effectiveness of in ovo feeding of vitamin C based on the embryonic vitamin C synthesis and absorption in broiler chickens

Journal of Animal Science and Biotechnology, 2021
Background Many researches about in ovo feeding (IOF) of vitamin C (VC) are gradually carried out to explore physiological development in chicken, but little studies focus on VC synthesis capacity of the embryo itself, the selection of injection site and
Yufei Zhu, Jianfei Zhao, Chenxu Wang, Fei Zhang, Xinhuo Huang, Zhouzheng Ren, Xin Yang, Yanli Liu, Xiaojun Yang   +8 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

LEAFY COTYLEDONs: old genes with new roles beyond seed development [version 1; peer review: 2 approved]

F1000Research, 2019
Seed development is a complex process and consists of two phases: embryo morphogenesis and seed maturation. LEAFY COTYLEDON (LEC) transcription factors, first discovered in Arabidopsis thaliana several decades ago, are master regulators of seed ...
De Niu, Yuehui He
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Expression pattern of the 10 mitogen-activated protein kinase kinases (MAPKK) encoded on Arabidopsis thaliana genome

Plant Signaling & Behavior
Phosphorylation, carried out by kinases, is a pivotal mechanism for all cell signal transduction pathways. In eukaryotic cells, Mitogen-Activated Protein Kinases (MAPK) form modules with three kinases (MAPKKK, MAPKK, and MAPK) that are sequentially ...
Salvador Barrera-Ortiz, José Manuel González-Coronel, Yessica Casales-Tlatilpa, Jesús Salvador López-Bucio, Julián David Camargo-Pacanchique, Ángel Arturo Guevara-García   +5 more
doaj   +1 more source

Thyroid hormone regulates distinct paths to maturation in pigment cell lineages

eLife, 2019
Thyroid hormone (TH) regulates diverse developmental events and can drive disparate cellular outcomes. In zebrafish, TH has opposite effects on neural crest derived pigment cells of the adult stripe pattern, limiting melanophore population expansion, yet
Lauren M Saunders, Abhishek K Mishra, Andrew J Aman, Victor M Lewis, Matthew B Toomey, Jonathan S Packer, Xiaojie Qiu, Jose L McFaline-Figueroa, Joseph C Corbo, Cole Trapnell, David M Parichy   +10 more
doaj   +1 more source

The post-embryonic development of Remipedia (Crustacea)—additional results and new insights [PDF]

Development Genes and Evolution, 2009
The post-embryonic development of a species of the enigmatic crustacean group Remipedia is described in detail for the first time under various aspects. Applying a molecular approach, we can clearly prove the species identity of the larvae as belonging to Pleomothra apletocheles.
Stefan, Koenemann, Jørgen, Olesen, Frederike, Alwes, Thomas M, Iliffe, Mario, Hoenemann, Petra, Ungerer, Carsten, Wolff, Gerhard, Scholtz   +7 more
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Postembryonic development of Loxosceles intermedia Mello-Leitão, 1934, L. laeta (Nicolet, 1849) and L. gaucho Gertsch, 1967 (Araneae; Sicariidae) breeding under conditions of monospecific diet [PDF]

Biotemas, 2005
The influence of monospecific feeding on the post-embryonic development of L. intermedia, L. laeta and L. gaucho was evaluated. Two hundred and ten spiderlings were individualized in containers (120 ml), 105 being fed with Tenebrio molitor larvae and 105
Emanuel Marques da Silva, Marta Luciane Fischer, Cesar Augusto Marchioro   +2 more
doaj