Results 51 to 60 of about 65,817 (260)

Risk factors for delayed post-exposure prophylaxis among Japanese travelers with animal bite exposure: A multicenter retrospective study

Travel Medicine and Infectious Disease
Introduction: Rabies is a fatal zoonotic disease; however, no comprehensive studies have been conducted on rabies prevention among Japanese travelers with animal exposure providing detailed information on pre-travel consultation, pre-exposure prophylaxis
Takehiro Hashimoto, Kei Yamamoto, Taku Ogawa, Issaku Nakatani, Nobuyuki Mishima, Shinji Fukushima, Akira Nishizono   +6 more
doaj   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

POPULATION KNOWLEDGE AND PERCEPTIONS ABOUT HIV, SEROPHOBIA, PREP, AND PEP IN FORTALEZA

Brazilian Journal of Infectious Diseases
Introduction/Objective: HIV infection remains a major global public health challenge, requiring integrated strategies for prevention, diagnosis, and treatment.
Vinicius Machado Salles, Mariana Jales Moura, Caroline Casemiro Gomes, Nathanael Willian Florencio de Freitas, Júlia Almeida Saraiva, Antonio Riquelme Martins Negreiros, Anna Paula Nogueira Nascimento, Thammy Lys Câmara Balbino, Manuel Eloy Leitão de Castro Junior, Lucas Passos Portácio Bezerra, Wirna Queiroz Belem Moreira, Lara Gurgel Fernandes Távora   +11 more
doaj   +1 more source

Determinants of abandonment of rabies post-exposure prophylaxis at the Bouaké Anti-rabies Center; Ivory Coast

Revue Malienne d’Infectiologie et de Microbiologie, 2017
In Côte d'Ivoire, a high number of exposed people abandoned the Post-Exposure Prophylaxis. Our objective was to determine the factors influencing the adherence to the Post-Exposure Prophylaxis  at the anti-rabies Center of Bouaké. Methods: we carried out
M'bégnan Coulibaly, Damus Paquin Kouassi, Henri auguste Yao Gnissan, Arsène Deby Kouame, N'Guessan Konan, Sory Ibrahim Soumahoro, Harvey Attoh-Toure, Issaka Tiembre   +7 more
doaj   +1 more source

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

Advanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai, Rhonda Kelley, Ying Lao, M. Immanuel Reyes Madlangsakay, Prasanta Paul, M. Alejandra Llanes‐Cuesta, Jun‐Feng Wang, René P. Zahedi, Jiming Kong, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

Biomimetic Gradient Hydrogels Regulate Osteochondral Regeneration Microenvironment Remodeling via Spatiotemporal Programming Engineering

Advanced Science, EarlyView.
Electric field‑driven continuous gradient hydrogel GHZF4 achieves spatiotemporal growth factor release, modulates immune microenvironment, angiogenesis and osteochondral differentiation. It realizes cell‑free functional osteochondral repair in rat/rabbit models, offering a promising biomimetic strategy for gradient tissue regeneration.
Xiaolian Niu, Shengzhao Xiao, Di Huang, Xuesong Wang, Yanwei Cao, Xiaodan Sun, Nicholas Dunne, Xiaoming Li   +7 more
wiley   +1 more source

Cobalt Single‐Atom Nanozyme for Enhanced Intestinal Radioprotection and Tumor Radiosensitization via Bidirectional ROS Modulation

Advanced Science, EarlyView.
Orally administered, pH‐responsive Co‐SAN exerts dual functions: in the alkaline intestinal milieu, it scavenges reactive oxygen species (ROS) and suppresses the PI3K/AKT pathway and NETs formation, thus providing radioprotection; whereas in the acidic tumor microenvironment, it generates ROS and alleviates hypoxia, thereby enhancing radiosensitization.
Shengqi Yin, Junjie Li, Yishu Zou, Yang Liu, Yilin Zheng, Lu Yu, Wanying Zheng, Yajun Zou, Zehui Zhang, Tao Li, Peiqun Yin, Jianlin Zhang, Yuen Wu, Yi Ding   +13 more
wiley   +1 more source

Predictors of linkage to prevention services after HIV post-exposure prophylaxis (PEP): A single-centre retrospective analysis, years 2019-2024

International Journal of Infectious Diseases
Objectives: Post-exposure prophylaxis (PEP) remains underutilised and real-world data on its role within prevention pathways are limited.We aimed to describe PEP use following sexual exposure and to identify predictors of linkage to prevention services ...
Rozenn Esvan, Giulia Micheli, Alessandro Giacinta, Alessandro Caioli, Virginia Barchi, Alessandra Oliva, Riccardo Schiavone, Alice Lener, Elisabetta Gennaro, Sara Passacantilli, Francesco Vairo, Paolo Faccendini, Andrea Antinori, Valentina Mazzotta   +13 more
doaj   +1 more source

How familiar are our doctors towards Rabies prophylaxis- A study from coastal south India.

PLoS Neglected Tropical Diseases, 2017
BackgroundRabies, a 100% fatal disease claims more than 59,000 human lives every year globally. One human life is lost every 15 minutes due to this deadly preventable disease.
Ramesh Holla, Bhagawan Darshan, Astha Guliani, Bhaskaran Unnikrishnan, Rekha Thapar, Prasanna Mithra, Nithin Kumar, Vaman Kulkarni, Avinash Kumar, Salman Anwar   +9 more
doaj   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source