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Post-finasteride syndrome - a true clinical entity?

International Journal of Impotence Research
This review critically examines Post-Finasteride Syndrome (PFS), a condition eventually reported by men who have used finasteride for androgenetic alopecia or benign prostatic enlargement and experienced persistent adverse effects after discontinuation. We explore the clinical manifestations, including sexual dysfunction, neuropsychiatric symptoms, and
Simone Cilio   +4 more
openaire   +2 more sources

Post‐finasteride syndrome: real or myth?

Trends in Urology & Men's Health
Men who report persistent sexual, neurological, and psychological side‐effects after discontinuing finasteride are said to have post‐finasteride syndrome. It is uncommon, but difficult for men suffering its effects. Although controversial, with no proven treatments, the syndrome should not be ignored.
openaire   +1 more source

Epigenetic Effects of Finasteride on Dopaminergic Signaling Pathways: A potential contributor to Post-Finasteride Syndrome

Physiology
Dopamine, a widely-distributed neurotransmitter in the brain and elsewhere, is important for regulating reward-motivated behavior, sexual impetus, concentration, pleasure, emotions, and genital arousal. Findings have previously implicated aberrant dopaminergic neurotransmission in mental disorders, as well as sexual and erectile dysfunction.
Churchill J Ihentuge, Antonei B Csoka
openaire   +1 more source

Framing the Problem: The Mystery of Post-Finasteride Syndrome and Reasons to Suspect a Microbial Factor

This paper expands upon a recently-proposed novel aetiology for Post-Finasteride Syndrome (PFS), hypothesizing that gut dysbiosis acts as a necessary "third factor" driving the condition's core features and diverse symptomatology. Currently, PFS is often attributed to permanent or temporary epigenetic silencing of the androgen receptor.
openaire   +1 more source

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