Results 161 to 170 of about 193,000 (260)

ZBTB11 Promotes Breast Cancer Progression by Activating FBXO28‐Mediated MST1 Degradation and Suppressing Hippo Signaling

Advanced Science, EarlyView.
ZBTB11 is identified as an oncogenic transcription factor that activates FBXO28 in breast cancer. FBXO28 promotes K48‐linked ubiquitination and degradation of MST1, suppressing Hippo signaling and enhancing epithelial–mesenchymal transition and metastasis. This transcription‐to‐ubiquitination cascade defines a prognostic biomarker axis and highlights a
An Xu, Xiang‐Nan Xu, Xiao Huang, Zhou Luo, Chun‐Lian Li, Yang Du, Cheng Yan, Xiao‐Jie Yu, Jian‐Wen Wang, Long‐Di Yao, De‐Yuan Fu   +10 more
wiley   +1 more source

Management of a Complex Orbital Post-transplantation Lymphoproliferative Disorder: A Case Report and Literature Review. [PDF]

In Vivo
Maruyama T, Hokama Y, Kishaba K, Kuninaka T, Kobayashi S, Nagamine H, Miyahira H, Tanaka K, Morichika K, Kawakami F, Tomita M, Wada N, Yogi A, Masuzaki H, Hamasaki T.   +14 more
europepmc   +1 more source

A Phosphorylation‐Induced Micellization Switch in the Low‐Complexity Domain of TDP‐43

Advanced Science, EarlyView.
Phosphorylation of TAR DNA‐binding protein's 43 kDa (TDP‐43) low‐complexity domain by casein kinase 1 delta (CK1δ) acts as a molecular switch, redirecting its self‐assembly from macroscopic phase separation toward finite‐sized, spherical block‐copolymer micelles of ∼30 nm.
Rodrigo F. Dillenburg, Anastasia Lopatina, Hao Ruan, Tom Scheidt, Simone Mosna, Emre Pekbilir, Julia Bieber, Frank Schäfer‐Depoix, Katharina Landfester, Carla Schmidt, Martin M. Möckel, Svenja Morsbach, Friederike Schmid, Dorothee Dormann, Lukas Stelzl, Martin Girard, Edward A. Lemke   +16 more
wiley   +1 more source

A Universal Protein Ladder for Standardization of Diverse FRET Assays

Advanced Science, EarlyView.
Translating FRET measurements from in vitro to intracellular environments requires universal benchmarks. We present a modular protein ladder using TPR motifs to harmonize data across diverse platforms. This predictable calibration curve bridges single molecule FRET measurements, with cell based measurements including FLIM‐FRET.
Evelyn R. Smith, Katie L. Gelder, Lewis Hunter‐Craig, Daniel A. Bose, Timothy D. Craggs, Alison E. Twelvetrees   +5 more
wiley   +1 more source

The WHOLE (We Humanize the One-Liner for Everyone) Patient Project-Re-Centering Social History in Oral Case Presentations. [PDF]

J Grad Med Educ
Ture A, Didwania A, Dolan B.
europepmc   +1 more source

A High‐Loading Zn Single‐Atom Nanozyme Targets the Zn/HIF‐1α/GLUT1 Axis to Disrupt Glucose Metabolic Reprogramming and Remodel the Tumor Immune Microenvironment

Advanced Science, EarlyView.
A high‐loading Zn single‐atom nanozyme (ZMG@CS) delivers ML‐SA5 and GOx to lysosomes. ML‐SA5 activates TRPML1 to release endogenous Zn2+, while the nanozyme provides exogenous Zn2+ and GOx‐driven acidification amplifies ROS production. Together, these effects suppress the HIF‐1α/GLUT1 axis, disrupt glucose and redox homeostasis, induce disulfidptosis ...
Zhenxin Wang, Yuhang Tang, Ronghao Yue, Jingtao Xu, Yong Tao, Jie Chen, Shipeng Li, Guosheng Zhao, Jinfang Xue, Mingwei Sun, Fenglei Gao, Yunsheng Ou, Yang Wang   +12 more
wiley   +1 more source

The UME-to-GME Transition Toolkit: Guidance for Stakeholders Across Medical Education. [PDF]

J Grad Med Educ
Sheets ZC, Behel J, Blumberg M, Cantone RE, Green E, Kaplan E, Moreland C, Ramy M, Ridgeway LS, Steelquist E, Verduzco-Gutierrez M, Passiment M, Charnsangavej N.   +12 more
europepmc   +1 more source

Selective Polarity Control of Metal Oxide Semiconductors for Complementary Logic Gates

Advanced Science, EarlyView.
A scalable electrochemical doping strategy enables in situ p‐to‐n polarity conversion in tin oxide (SnO) thin films using electrolyte gating. Both the pristine p‐type SnO transistor and the electrochemically converted n‐type SnO2 transistor exhibited noticeable and stable electrical performance.
Dong Hyun Park, Seung Ho Ryu, Min Su Kim, Taek‐Mo Chung, Seong Keun Kim, In‐Hwan Baek, Keun Hyung Lee   +6 more
wiley   +1 more source

WCN25-1678 HIGH DOSE ERYTHROPOIETIN VERSUS DESIDUSTAT FOR TREATMENT OF ANEMIA IN PATIENTS OF CHRONIC KIDNEY DISEASE HAVING INADEQUATE RESPONSE TO WEIGHT BASED ERYTHROPOIETIN DOSE: PROSPECTIVE OBSERVATIONAL STUDY

Kidney International Reports
Smita Divyaveer, Harbir Singh Kohli, Deepy Zohmangaihi, Nabhajit Mallik, Kushal Kekan, Arun Prabhahar, Madhuri Kashyap, Kanchan Prajapati   +7 more
doaj   +1 more source

Can experiential learning boost dental ergonomics? evaluating a microscope-based curriculum through Kirkpatrick's model. [PDF]

BMC Oral Health
Li Z, Xia Y, Chen Y, Huang C, Liang S.
europepmc   +1 more source