Results 31 to 40 of about 203,484 (260)

VITAMIN D INSUFFICIENCY: WHAT’S NEW?

Вопросы современной педиатрии, 2014
Currently, scientists are continuing discussions on the definition of the precise level of vitamin D in the blood serum, but there is a consensus that vitamin D insufficiency is common throughout the world and has an adverse effect on human health.
I. N. Zakharova, Yu. A. Dmitrieva, S. V. Yablochkova, E. A. Evseeva   +3 more
doaj   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

LEVELS OF SYSTEMIC INFLAMMATORY RESPONSE MARKERS IN PATIENTS WITH PULMONARY HYPERTENSION AND COPD

Східноукраїнський медичний журнал, 2020
Introduction. The prevalence of COPD worldwide is about 7.6 %, and it is one of the main causes of morbidity and mortality in today society. Today, much information has been obtained about the pathogenetic mechanisms of COPD development.
I. M. Fushtey, K. L. Nikolaieva, E. V. Sid’   +2 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Outcomes of OCT imaging-based reoperations in strabismus

BMC Ophthalmology
Purpose Reoperations in strabismus are reportedly needed in 20–40% of cases undergoing surgery. The present study investigated the outcomes of reoperations based on preoperative imaging of extraocular muscle insertions, and whether the Anterior Segment ...
Savleen Kaur, Jaspreet Sukhija, Srishti Raj, Shweta Chaurasia, Shubhi Singh M. Optom   +4 more
doaj   +1 more source

Medical and biological functions of water

Фармацевтичний журнал, 2019
Water is the most common compound of hydrogen and oxygen in the nature. It is a universal solvent of many substances, and therefore chemically pure water does not exist in the nature.
R. S. Korytniuk, L. L. Davtian, N. I. Hudz, A. A. Drozdova, I. О. Vlasenko, M. V. Leleka, T. F. Olifirova   +6 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Feasibility and effectiveness of a hybrid teleaudiology model for accessible hearing healthcare: a mixed-methods study in Northern India

The Egyptian Journal of Otolaryngology
Background An estimated 63 million people in India have disabling hearing loss, yet access to hearing healthcare remains limited due to high costs, long travel distances, severe shortage of audiologists, and low awareness.
Md Noorain Alam, Sanjay Kumar Munjal, Sagrika Sharma, Jaimanti Bakshi, Naresh Kumar Panda   +4 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source