Results 131 to 140 of about 12,754,412 (324)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Post-Growth Geographies: Spatial Relations of Diverse and Alternative Economies

, 2023
Post-Growth Geographies examines the spatial relations of diverse and alternative economies between growth-oriented institutions and multiple socio-ecological crises.
Schmid, Benedikt, Schulz, Christian, Lange, Bastian, Hülz, Martina   +3 more
core   +1 more source

Selection and adoption of water purification technologies in the bottled water industry in India

Cleaner Water
Today, more than sixty per cent of the global bottled water manufacturing takes place in the countries of the global south. Despite being a low-tech sector, the industry is heavily influenced by the advancement and adoption of new water purification ...
Aviram Sharma, Saradindu Bhaduri
doaj   +1 more source

The EU Industrial Strategy: Towards a Post-Growth Agenda? [PDF]

Inter Econ, 2021
Renda A.
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Indifferent, Dogmatic or Pragmatic: A Multi-Country Analysis of How Scientists View the Public and Public Engagement

Sociologica
How do scientists view the public and think about public engagement? In this article, we analyze interview data from 205 scientists in the fields of biology and physics from four countries — India, Italy, UK, and the USA — to show that scientists do not ...
Poonam Pandey, Stefano Sbalchiero, Cesare Silla, Brandon Vaidyanathan   +3 more
doaj   +1 more source

The stability of graphene and boron nitride for III-nitride epitaxy and post-growth exfoliation. [PDF]

Chem Sci, 2021
Park JH, Yang X, Lee JY, Park MD, Bae SY, Pristovsek M, Amano H, Lee DS.   +7 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Post-Growth Solutions for Social Resilience

Due to the complex, novel and dynamic nature of contemporary crises and future extreme events, creative solutions, concepts and strategies need to be defined and implemented in order to strengthen the resilience of affected social systems, such as ...
Gnamm, Mats-Benjamin
core   +1 more source