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prospective multicenter validation of preoperative plasma ceramides as novel predictive biomarkers for clinically relevant post-hepatectomy liver failure

Hanbiao Liang, Haiqing Liu, Jieyuan Li, Biao Wang, Pengxiang Huang, Weiyi Guo, Baoxiong Zhuang, Leyi Liao, Qingping Li, Xianqiu Wu, Tianzhou Peng, Zhanhong Lai, Shanhua Tang, Bowen Zhu, Jing Gao, Shiyu Lin, Can Huang, Cuiting Liu, Minghui Zeng, Jianping Qian, Qifan Zhang, Jie Zhou, Xuesong Deng, Chuanjiang Li, Kai Wang   +24 more
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Post-hepatectomy liver failure: A timeline centered review

Hepatobiliary & Pancreatic Diseases International, 2023
Post-hepatectomy liver failure (PHLF) is a leading cause of postoperative mortality after liver surgery. Due to its significant impact, it is imperative to understand the risk stratification and preventative strategies for PHLF. The main objective of this review is to highlight the role of these strategies in a timeline centered way around curative ...
Mohamed, Bekheit, Lisa, Grundy, Ahmed Ka, Salih, Petru, Bucur, Eric, Vibert, Mudassar, Ghazanfar   +5 more
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New Paradigms in Post-hepatectomy Liver Failure

Journal of Gastrointestinal Surgery, 2013
Liver failure after hepatectomy remains the most feared postoperative complication. Many risk factors are already known, related to patient's comorbidities, underlying liver disease, received treatments and type of resection. Preoperative assessment of functional liver reserve must be a priority for the surgeon.Physiopathology of post-hepatectomy liver
Nicolas Golse, Petru Bucur, D. Castaing, Antonio Sa Cunha, Eric Vibert, Eric Vibert, René Adam   +6 more
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Post Hepatectomy Liver Failure: Concept of Management

Journal of Gastrointestinal Cancer, 2014
In literature, the reported mortality of posthepatectomy liver failure is
Kaushal Yadav, Shailesh V. Shrikhande, Mahesh Goel   +2 more
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Post-hepatectomy liver failure in patients with colorectal liver metastases

Surgery Today, 2015
Liver resection remains the standard treatment for colorectal liver metastases (CLM). Major hepatic resection is now performed frequently and with relative safety, but postoperative mortality is still reported to occur in up to 6 % of the patients with CLM undergoing liver resection even at high-volume centers.
Shinji Uemoto, Elie Oussoultzoglou, Masato Narita, Daniel Jaeck, Philippe Bachellier   +4 more
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Development of a Porcine Model of Post-Hepatectomy Liver Failure

Journal of Surgical Research, 2011
The aim of this study was to develop a porcine model of post-operative liver failure (POLF) that could accurately reproduce all the neurological and metabolic parameters of the corresponding clinical syndrome that may develop after extensive liver resections.In our model, we induced POLF by combining extended left hepatectomy and ischemia of the small ...
Georgios Defterevos, Vassilios Smyrniotis, Apostolos Papalois, Georgia Kostopanagiotou, Dimosthenis Kypriotis, Agathi Pafiti, Konstantinos Kalimeris, Nikolaos Arkadopoulos, Georgios Kampouroglou, Nikolaos Papoutsidakis, Constantinos Nastos   +10 more
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The role of imaging in prediction of post-hepatectomy liver failure

Clinical Imaging, 2018
Post-hepatectomy liver failure (PHLF) is not only a leading cause of mortality but also a leading cause of life-threatening complications in patients undergoing liver resection. The ability to accurately detect the emergence of PHLF represents a crucially important step.
Yao Pan, Yinan Shen, Meng-Lin Zheng, Wei-Yun Yao, Xueli Bai, Tingbo Liang, Cheng-Xiang Guo   +6 more
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Post-hepatectomy Liver Failure

2017
Among postoperative complications associated with liver surgery, such as infections, fluid collections, deep venous thrombosis, bleeding, and bile leak, liver insufficiency/failure is typically the most life-threatening condition. In fact, post-hepatectomy liver failure (PHLF) can be the cause of serious morbidity and mortality after liver resection ...
Timothy M. Pawlik, Gaya Spolverato, Gaya Spolverato, Fabio Bagante, Fabio Bagante   +4 more
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Intraoperative severe hypoglycemia indicative of post-hepatectomy liver failure

Journal of Anesthesia, 2015
We present the first reported case of a patient with intraoperative hypoglycemia, with no predisposing factors, that was indicative of post-hepatectomy liver failure due to liver injury. A 56-year-old man was hospitalized to undergo left lateral segmentectomy, cholecystectomy and T-tube choledocholithotripsy due to calculi in the intrahepatic and ...
Seunguk Bang, Kyudon Chung, Yoona Kim, Hyuntae Chang   +3 more
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Does the Surgical Approach Affect the Incidence of Post-Hepatectomy Liver Failure in Cirrhotic Patients? An Analysis of the NSQIP Database

The American surgeon
Background: The association between surgical approach and post-hepatectomy liver failure (PHLF) in cirrhotic patients is poorly understood. We hypothesize that patients will have similar rates of liver failure regardless of whether they undergo minimally
Faisal S. Jehan, Sangrag Ganguli, Niklas E. Hase, Abhinav Seth, Yong K. Kwon, Alan W. Hemming, Hassan Aziz   +6 more
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