Results 121 to 130 of about 2,839,497 (322)

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Development of an R script for simple lipidomic and metabolomic data analysis [PDF]

, 2020
Background: Metabolomic and lipidomic studies generate vast quantities of data that are often analysed in a closed software environment with little to no access to the underlying algorithms.
Alshammari, Suad, Alsultan, Monther, Contaifer, Daniel, Morriss, Joshua M., Wijesinghe, Dayanjan S.   +4 more
core   +1 more source

Spirometric changes during exacerbations of COPD: a post hoc analysis of the WISDOM trial

Respiratory Research, 2018
Background Exacerbations of chronic obstructive pulmonary disease (COPD) are associated with loss of lung function and poor outcomes for patients. However, there are limited data on the time course of changes in forced expiratory volume in 1 s (FEV1 ...
Henrik Watz, Kay Tetzlaff, Helgo Magnussen, Achim Mueller, Roberto Rodriguez-Roisin, Emiel F. M. Wouters, Claus Vogelmeier, Peter M. A. Calverley   +7 more
doaj   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

Kepler White Paper: Asteroseismology of Solar-Like Oscillators in a 2-Wheel Mission

, 2013
We comment on the potential for continuing asteroseismology of solar-type and red-giant stars in a 2-wheel Kepler Mission. Our main conclusion is that by targeting stars in the ecliptic it should be possible to perform high-quality asteroseismology, as ...
Aguirre, V. Silva, Appourchaux, T., Arentoft, T., Ball, W., Basu, S., Beck, P. G., Bedding, T. R., Birch, A. C., Brogaard, K., Buzasi, D. L., Campante, T. L., Casagrande, L., Cellier, T., Chaplin, W. J, Christensen-Dalsgaard, J., Corsaro, E., Creevey, O. L., Davies, G. R., De Ridder, J., Deheuvels, S., Dogan, G., Elsworth, Y., Garcia, R. A., Gilliland, R. L., Gizon, L., Grundahl, F., Guzik, J., Handberg, R., Hekker, S., Houdek, G., Huber, D., Jimenez, A., Kallinger, T., Karoff, C., Kawaler, S. D., Kjeldsen, H., Lund, M. N., Lundkvist, M., Mathis, S., Mathur, S., Mazumdar, A., Metcalfe, T. S., Miglio, A., Molenda-Zakowicz, J., Monteiro, M. J. P. F. G., Mosser, B., Neiner, C., Nielsen, M. B., Palle, P. L., Pinsonneault, M. H., Salabert, D., Schou, J., Serenelli, A. M., Shunker, H., Stello, D., White, T. R.   +55 more
core  

Gender differences in tuberculosis treatment outcomes: a post hoc analysis of the REMoxTB study

BMC Medicine, 2018
Background In the REMoxTB study of 4-month treatment-shortening regimens containing moxifloxacin compared to the standard 6-month regimen for tuberculosis, the proportion of unfavourable outcomes for women was similar in all study arms, but men had more ...
M. E. Murphy, G. H. Wills, S. Murthy, C. Louw, A. L. C. Bateson, R. D. Hunt, T. D. McHugh, A. J. Nunn, S. K. Meredith, C. M. Mendel, M. Spigelman, A. M. Crook, S. H. Gillespie, for the REMoxTB consortium   +13 more
doaj   +1 more source

Association Between Change in Visual Acuity and Change in Central Subfield Thickness During Treatment of Diabetic Macular Edema in Participants Randomized to Aflibercept, Bevacizumab, or Ranibizumab: A Post Hoc Analysis of the Protocol T Randomized Clinical Trial.

JAMA ophthalmology, 2019
Importance The determination of optical coherence tomography (OCT) central subfield thickness (CST) is an objective measure, and visual acuity (VA) is a subjective measure.
N. Bressler, Isoken Odia, M. Maguire, A. Glassman, L. Jampol, M. MacCumber, C. Shah, D. Rosberger, Jennifer K. Sun   +8 more
semanticscholar   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

'R.I.P. man...u are missed and loved by many': entextualising moments of mourning on a Facebook Rest in Peace group site [PDF]

, 2014
Digital media offer new domains for people to articulate aspects of their everyday selves, as well as to share resources, views, attitudes, and emotions on an unprecedented scale (Barton and Lee 2013; Georgakopoulou 2006; Jones and Hafner 2012).
Giaxoglou, Korina
core  

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source