Results 131 to 140 of about 2,839,497 (322)

Acute neuroinflammation induces AIS structural plasticity in a NOX2-dependent manner [PDF]

, 2017
Background Chronic microglia-mediated inflammation and oxidative stress are well-characterized underlying factors in neurodegenerative disease, whereby reactive inflammatory microglia enhance ROS production and impact neuronal integrity. Recently, it has
Benusa, S. D., DeVries, G. H., Dupree, J. L., George, N. M., Sword, B. A.   +4 more
core   +1 more source

Pooled post hoc analysis of population pharmacokinetics of oxycodone and acetaminophen following a single oral dose of biphasic immediate-release/extended-release oxycodone/acetaminophen tablets

Drug Design, Development and Therapy, 2015
Ryan M Franke, Terri Morton, Krishna Devarakonda Department of Clinical Pharmacology, Mallinckrodt Pharmaceuticals, Hazelwood, MO, USA Abstract: This analysis evaluated the single-dose population pharmacokinetics (PK) of biphasic immediate-release (IR)/
Franke RM, Morton T, Devarakonda K
doaj  

COPD associated pulmonary hypertension: A post hoc analysis of the PERFECT study

Pulmonary Circulation
The PERFECT study, a randomized, controlled, double‐blind study of inhaled treprostinil in patients with COPD and associated pulmonary hypertension (PH‐COPD) was a negative trial that was terminated early.
Steven D. Nathan, Victoria Lacasse, Heidi Bell, Prakash Sista, Michael Di Marino, Todd Bull, Victor Tapson, Aaron Waxman   +7 more
doaj   +1 more source

A Post Hoc Holter ECG Analysis of Olodaterol and Formoterol in Moderate-to-Very-Severe COPD

International Journal of COPD, 2020
Stefan Andreas,1,2 Ulrich Bothner,3 Alberto de la Hoz,3 Isabel Kloer,3 Matthias Trampisch,3 Peter Alter4 1Department of Cardiology and Pneumology, University Medical Center Göttingen, Göttingen, Germany; 2LungClinic Immenhausen, Immenhausen ...
Andreas S, Bothner U, de la Hoz A, Kloer I, Trampisch M, Alter P   +5 more
doaj  

Effects of tirzepatide versus insulin glargine on kidney outcomes in type 2 diabetes in the SURPASS-4 trial: post-hoc analysis of an open-label, randomised, phase 3 trial.

The Lancet Diabetes and Endocrinology, 2022
H. Heerspink, N. Sattar, I. Pávó, A. Haupt, K. Duffin, Zhengyu Yang, R. Wiese, K. Tuttle, D. Cherney   +8 more
semanticscholar   +1 more source

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Clearcutting in Appalachia: Impacts on Stream Water Quality in an Appalachian Watershed [PDF]

, 2019
Clearcutting forests has the potential to impact the water quality of high water headwater streams. In this study, we measured the effect of forest clearcut events on parameters of stream water quality within Michaux State Forest.
Kaewwilai, Alyssa J., Peterson, Hannah R., Rec, Abigail F.   +2 more
core   +1 more source

Conservative oxygen therapy for mechanically ventilated adults with sepsis: a post hoc analysis of data from the intensive care unit randomized trial comparing two approaches to oxygen therapy (ICU-ROX)

Intensive Care Medicine, 2019
Purpose Sepsis is a common reason for intensive care unit (ICU) admission and mortality in ICU patients. Despite increasing interest in treatment strategies limiting oxygen exposure in ICU patients, no trials have compared conservative vs.
P. Young, D. Mackle, R. Bellomo, M. Bailey, R. Beasley, A. Deane, G. Eastwood, S. Finfer, R. C Freebairn, Victoria L. King, N. Linke, E. Litton, C. McArthur, S. McGuinness, R. Panwar   +14 more
semanticscholar   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source