ALS plasma biomarkers reveal neurofilament and pTau correlate with disease onset and progression
Annals of Clinical and Translational Neurology, Volume 12, Issue 4, Page 714-723, April 2025.Abstract Objective We performed a pilot screen to assess the utility of the NULISA™ (Nucleic‐acid‐Linked Immuno‐Sandwich Assay) platform in the identification of amyotrophic lateral sclerosis (ALS) biomarkers. Methods Plasma from 86 individuals (48 ALS, 18 asymptomatic C9orf72 repeat expansion carriers (AsymC9), and 20 healthy controls) was analyzed ...
Eleanor V. Thomas +10 more
wiley +1 more source
Introductory Clifford Analysis [PDF]
arXiv, 2003 This paper is an elaboration of an introductory talk given by the author at a workshop on Clifford algebras at Tennessee Technical University, in May 2002. We give an introduction to the basic concepts of Clifford analysis, including links to harmonic analysis, Fourier analysis and conformally flat manifolds.
arxiv
Capturing what matters: Patient‐reported LGI1‐ANTibody encephalitis outcome RatiNg scale (LANTERN)
Annals of Clinical and Translational Neurology, Volume 12, Issue 4, Page 821-831, April 2025.Abstract Background LGI1‐antibody encephalitis (LGI1‐Ab‐E) is a common form of autoimmune encephalitis where most patients demonstrate ‘good’ clinician‐rated outcomes. However, more targeted questionnaires reveal numerous debilitating symptoms for many years.
Mark J Kelly +9 more
wiley +1 more source
Ultrasound protocols to measure carotid intima–media thickness: a post-hoc analysis of the OPAL study [PDF]
, 2008 Soner Doğan +5 more
openalex +1 more source
Amygdala Neurodegeneration: A Key Driver of Visual Dysfunction in Parkinson's Disease
Annals of Clinical and Translational Neurology, Volume 12, Issue 4, Page 768-779, April 2025.ABSTRACT Objective Visual disability in Parkinson's disease (PD) is not fully explained by retinal neurodegeneration. We aimed to delineate the brain substrate of visual dysfunction in PD and its association with retinal thickness. Methods Forty‐two PD patients and 29 controls underwent 3‐Tesla MRI, retinal spectral‐domain optical coherence tomography,
Asier Erramuzpe +15 more
wiley +1 more source
Post hoc analysis and claims of superiority in the excel trial [PDF]
Respiratory Medicine, 2007 Tomas Andersson, Ian Naya
openaire +3 more sources
Progressive Myoclonus Epilepsy: Distinctive MRI Changes in Cerebellar and Motor Networks
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Progressive myoclonus epilepsy (PME) is a rare generalized epilepsy syndrome with a well‐characterized genetic basis. The brain networks that are affected to give rise to the distinctive symptoms of PME are less well understood. Methods Eleven individuals with PME with a confirmed genetic diagnosis and 22 controls were studied.
Jillian M. Cameron +3 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Certain frontotemporal lobar degeneration subtypes, including TDP‐A and B, can either occur sporadically or in association with specific genetic mutations. It is uncertain whether syndromic or imaging features previously associated with these patient groups are subtype or genotype specific.
Sean Coulborn +17 more
wiley +1 more source
P18.06: Clinical trials in fetal interventions: a post-hoc Bayesian analysis of the Eurofetus trial [PDF]
, 2009 J. Stirnemann +2 more
openalex +1 more source
Early Language Impairment as an Integral Part of the Cognitive Phenotype in Huntington's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Huntington's disease (HD) speech/language disorders have typically been attributed to motor and executive impairment due to striatal dysfunction. In‐depth study of linguistic skills and the role of extrastriatal structures in HD is scarce.
Arnau Puig‐Davi +13 more
wiley +1 more source