Results 11 to 20 of about 2,152,009 (360)

Initiating angiotensin II at lower vasopressor doses in vasodilatory shock: an exploratory post-hoc analysis of the ATHOS-3 clinical trial

Critical Care, 2023
Background High dose vasopressors portend poor outcome in vasodilatory shock. We aimed to evaluate the impact of baseline vasopressor dose on outcomes in patients treated with angiotensin II (AT II).
P. Wieruszewski, R. Bellomo, L. Busse, Kealy R. Ham, A. Zarbock, A. Khanna, A. Deane, M. Ostermann, R. Wunderink, David W. Boldt, Stew Kroll, Charles R. Greenfeld, Tony Hodges, J. Chow   +13 more
semanticscholar   +1 more source

Clinical Remission in Severe Asthma: A Pooled Post Hoc Analysis of the Patient Journey with Benralizumab

Advances in Therapy, 2022
Consensus definitions for clinical remission and super-response were recently established for severe asthma. Benralizumab is an interleukin-5 (IL-5) receptor α-directed monoclonal antibody for severe, uncontrolled asthma; efficacy and safety were ...
A. Menzies-Gow, F. Hoyte, D. Price, D. Cohen, P. Barker, J. Kreindler, M. Jison, Christopher L. Brooks, Peggy Papeleu, R. Katial   +9 more
semanticscholar   +1 more source

Effects of switching from a metered dose inhaler to a dry powder inhaler on climate emissions and asthma control: post-hoc analysis

Thorax, 2022
Objective To compare the effects of switching from a pressurised metered dose inhaler (pMDI)-based to a dry powder inhaler (DPI)-based maintenance therapy versus continued usual care on greenhouse gas emissions (carbon dioxide equivalents, CO2e) and ...
A. Woodcock, C. Janson, J. Rees, L. Frith, Magnus Löfdahl, Alison C. Moore, Martin Hedberg, D. Leather   +7 more
semanticscholar   +1 more source

Effect of dapagliflozin on kidney and cardiovascular outcomes by baseline KDIGO risk categories: a post hoc analysis of the DAPA-CKD trial

Diabetologia, 2022
In the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease (DAPA-CKD) trial, dapagliflozin reduced the risks of progressive kidney disease, hospitalised heart failure or cardiovascular death, and death from all causes in patients ...
Simke W. Waijer, P. Vart, D. Cherney, G. Chertow, N. Jongs, A. Langkilde, JohannesF. E. Mann, Ofri Mosenzon, J. McMurray, P. Rossing, R. Correa-Rotter, B. Stefánsson, R. Toto, D. Wheeler, Hiddo J. L. Heerspink   +14 more
semanticscholar   +1 more source

The number of risk factors not at target is associated with cardiovascular risk in a type 2 diabetic population with albuminuria in primary cardiovascular prevention. Post-hoc analysis of the NID-2 trial

Cardiovascular Diabetology, 2022
Background Nephropathy in Diabetes type 2 (NID-2) study is an open-label cluster randomized clinical trial that demonstrated that multifactorial intensive treatment reduces Major Adverse Cardiac Events (MACEs) and overall mortality versus standard of ...
F. C. Sasso, V. Simeon, R. Galiero, A. Caturano, L. De Nicola, P. Chiodini, L. Rinaldi, T. Salvatore, Miriam Lettieri, R. Nevola, C. Sardu, Giovanni Docimo, G. Loffredo, R. Marfella, L. Adinolfi, R. Minutolo, U C P O G G M R A L N E G A S L L A A A N S P V P R Amelia Acierno Calatola Carbonara Conte Corigliano, U. Amelia, C. Acierno, P. Calatola, O. Carbonara, G. Conte, G. Corigliano, M. Corigliano, R. D’Urso, A. De Matteo, L. De Nicola, N. De Rosa, E. Del Vecchio, G. di Giovanni, A. Gatti, S. Gentile, L. Gesuè, L. Improta, A. LampitellaJr, A. Lampitella, A. Lanzilli, N. Lascar, S. Masi, P. Mattei, V. Mastrilli, P. Memoli, R. Minutolo, R. Nasti, A. Pagano, M. Pentangelo, E. Pisa, E. Rossi, F. C. Sasso, S. Sorrentino, R. Torella, R. Troise, P. Trucillo, A. Turco, S. Turco, F. Zibella, L. Zirpoli   +56 more
semanticscholar   +1 more source

The Effects of Safinamide Adjunct Therapy on Depression and Apathy in Patients With Parkinson's Disease: Post-hoc Analysis of a Japanese Phase 2/3 Study

Frontiers in Neurology, 2022
Background and PurposeNeuropsychiatric symptoms in Parkinson's disease (PD) have been shown to significantly affect quality of life (QOL). We investigated the impact of safinamide on depression and apathy when administered as an adjunct to levodopa in ...
Nobutaka Hattori, Yuki Kogo, Michinori Koebis, Takayuki Ishida, Ippei Suzuki, Yoshio Tsuboi, Masahiro Nomoto   +6 more
doaj   +1 more source

Effects of Semaglutide on Stroke Subtypes in Type 2 Diabetes: Post Hoc Analysis of the Randomized SUSTAIN 6 and PIONEER 6

Stroke, 2022
Background: GLP-1 RA (glucagon-like peptide-1 receptor agonists), including semaglutide, may reduce stroke risk in people with type 2 diabetes. This post hoc analysis examined the subcutaneous and oral semaglutide effects, versus placebo, on stroke and ...
W. Strain, O. Frenkel, M. James, Lawrence A Leiter, S. Rasmussen, P. Rothwell, Maria Sejersten Ripa, T. Truelsen, M. Husain   +8 more
semanticscholar   +1 more source

Efficacy of Pirfenidone vs. Placebo in Unclassifiable Interstitial Lung Disease, by Surgical Lung Biopsy Status: Data From a post-hoc Analysis

Frontiers in Medicine, 2022
Approximately 12–13% of patients with interstitial lung disease (ILD) are diagnosed with unclassifiable ILD (uILD), often despite thorough evaluation. A recent Phase 2 study (NCT03099187) described a significant effect of pirfenidone vs.
Maria Molina-Molina, Maria Molina-Molina, Michael Kreuter, Michael Kreuter, Vincent Cottin, Vincent Cottin, Tamera J. Corte, Tamera J. Corte, Frank Gilberg, Klaus-Uwe Kirchgaessler, Judit Axmann, Toby M. Maher, Toby M. Maher, Toby M. Maher   +13 more
doaj   +1 more source

Risk of major adverse cardiovascular events with tofacitinib versus tumour necrosis factor inhibitors in patients with rheumatoid arthritis with or without a history of atherosclerotic cardiovascular disease: a post hoc analysis from ORAL Surveillance

Annals of the Rheumatic Diseases, 2022
Objectives Evaluate risk of major adverse cardiovascular events (MACE) with tofacitinib versus tumour necrosis factor inhibitors (TNFi) in patients with rheumatoid arthritis (RA) with or without a history of atherosclerotic cardiovascular disease (ASCVD)
C. Charles-Schoeman, M. Buch, M. Dougados, Deepak L. Bhatt, J. Giles, S. Ytterberg, G. Koch, I. Vranic, Joseph Wu, Cunshan Wang, K. Kwok, S. Menon, J. Rivas, A. Yndestad, C. Connell, Z. Szekanecz   +15 more
semanticscholar   +1 more source

Perceived Overqualification Repatriates: Post Hoc Analysis for Traditional and Alternative Forms

Journal of International Business, Economics and Entrepreneurship, 2022
Repatriates perceived the discrepancy in utilizing their enhanced international experiences upon returning home, resulting in them being perceived as being overqualified, and led to low retention rates.
Maggie Mei Kei Chong, Raida Abu Bakar, Sharmila Jayasingam   +2 more
doaj   +3 more sources