Results 311 to 320 of about 2,152,009 (360)

Mechanically and Chemically Defined PEG Hydrogels Improve Reproducibility in Human Cardioid Development

open access: yesAdvanced Healthcare Materials, EarlyView.
Synthetic matrix metalloproteinase (MMP)‐degradable polyethylene glycol (PEG)‐based hydrogels are developed to investigate the influence of mechanical and biochemical cues on cardioid development. Matrix stiffness and cell adhesion motifs significantly regulate cardioid formation, chamber morphogenesis, contractile function, and cardioid transcriptome.
Yuanhui Song   +6 more
wiley   +1 more source

<i>TP53</i> deletion as an MRD-dependent risk factor in childhood B-ALL: A post hoc analysis from a prospective cohort. [PDF]

open access: yesHemasphere
Gao Y   +13 more
europepmc   +1 more source

Supramolecular Additive Screening to Engineer Microfibrous Rafts for Expansion of Pluripotent Stem Cells in Dynamic Suspension

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 11, April 25, 2025.
Segmented PCL‐bisurea (BU) polymers and BU‐peptide conjugate additives assemble into fibrous superstructures at the nanoscale through a mix‐and‐matching strategy. Different bioactivities are incorporated through variation of peptide sequences. The resulting materials are screened for their effect on stem cell adhesion and pluripotency.
Johnick F. van Sprang   +6 more
wiley   +1 more source

In Vivo‐Like Scaffold‐Free 3D In Vitro Models of Muscular Dystrophies: The Case for Anchored Cell Sheet Engineering in Personalized Medicine

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 12, May 6, 2025.
The scaffold‐free Anchored Cell Sheet Engineering platform is used to create three‐dimensional (3D) in vitro models of skeletal muscle tissue that replicate key features of Duchenne and Myotonic dystrophies. These personalized tissue models, validated by histological, immunostaining, and proteomics analyses, accurately mimic disease phenotypes and ...
Alireza Shahin‐Shamsabadi   +1 more
wiley   +1 more source

Novel Protein‐Rich Bioactive Bioink Stimulates Cellular Proliferation and Response in 3D Bioprinted Volumetric Constructs

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 10, April 15, 2025.
This work describes a protein‐rich, low‐cost, bioactive bioink, prepared by adding eggwhite powder to functionalize an established alginate‐methylcellulose hydrogel blend and enhance its cellular response. The bioink not only maintains favorable printability and high shape fidelity but also exhibits remarkable bioactivity, thereby improving the ...
Suihong Liu   +8 more
wiley   +1 more source

Time spent in glycaemic control with sustained body weight reduction with tirzepatide: A post hoc analysis of the SURPASS clinical trial programme. [PDF]

open access: yesDiabetes Obes Metab
Bergman BK   +8 more
europepmc   +1 more source

Endogenous Protein‐Modified Gold Nanorods as Immune‐Inert Biomodulators for Tumor‐Specific Imaging and Therapy

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
Engineered modifications of nanomaterials inspired by nature hold great promise for disease‐specific imaging and therapy. Inspired by nature, gold nanorods modified by endogenous proteins (eP@Au) are proposed as ingenious biomodulators for enhanced tumor therapy with reduced off‐target effects.
Chunyan Fang   +6 more
wiley   +1 more source

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