Results 61 to 70 of about 1,619,670 (307)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Post hoc analysis of age and working experiences variables.

, 2022
Post hoc analysis of age and working experiences variables.
Rawan Abdeen (12342425)
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Post-hoc analysis including participants who at baseline assessment reported their job to be very physically demanding (crude estimates).

, 2019
Post-hoc analysis including participants who at baseline assessment reported their job to be very physically demanding (crude estimates).
Lars Erik Kristensen (7255865), Bjarke Brandt Hansen (7255853), Mikael Boesen (3469199), Henning Bliddal (449460), Lilli Kirkeskov (7255856), Ditte Lundsgaard Andreasen (7255862), Ann Isabel Kryger (7255871), Esben Meulengracht Flachs (7255868), Robin Christensen (632413), Luise Moelenberg Begtrup (7255859)   +9 more
core   +1 more source

LMEMs for post-hoc analysis of HPO Benchmarking

CoRR
The importance of tuning hyperparameters in Machine Learning (ML) and Deep Learning (DL) is established through empirical research and applications, evident from the increase in new hyperparameter optimization (HPO) algorithms and benchmarks steadily added by the community.
Anton Geburek, Neeratyoy Mallik, Danny Stoll, Xavier Bouthillier, Frank Hutter   +4 more
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Selection of post-hoc analysis cohort.

, 2019
Selection of post-hoc analysis cohort.
Rachel G. Khadaroo (7817099), Diana Rucker (7817090), Lindsey M. Warkentin (7817093), Hanhmi Huynh (7817096)   +3 more
core   +1 more source

Post hoc analysis of endoscopic submucosal dissection parameters.

, 2021
Post hoc analysis of endoscopic submucosal dissection parameters.
Han Jo Jeon (11820328), Sang Hyun Kim (8720874), Eun Sun Kim (843999), Yoon Tae Jeen (10963681), Hyuk Soon Choi (11576164), Jae Min Lee (7293191), Kang Won Lee (8918654), Jong Hyuk Kim (10057816), Bora Keum (844000), Hoon Jai Chun (843996), Eun Ju Bang (11820331), Seung Jeong (11820337), Hong Sik Lee (11820334)   +12 more
core   +1 more source