Results 61 to 70 of about 6,663,865 (308)

The Post-implementation Assessment of Advanced Technology Utilization [PDF]

Journal of Competitiveness, 2012
Efficient utilization of advanced manufacturing technology is usually seen as one of the crucial factors in achieving competitiveness on global markets. On the other hand, there are many problems associated with the advanced technology utilization. These
Hynek Josef, Janecek Vaclav
doaj  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Annual report : Legislative Post Audit Committee and the Legislative Division of Post Audit, fiscal year 1983.

, 1983
"A Report to the Kansas Legislature by the Legislative Post Audit Committee, state of Kansas."; "July 28, 1983."Constitutes the annual report of the ...
Kansas. Legislative Post Audit Committee.
core  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Annual report : Legislative Post Audit Committee and the Legislative Division of Post Audit, fiscal year 1980.

, 1980
"A Report to the Kansas Legislature by the Legislative Post Audit Committee, state of Kansas."; "December 1, 1980."Constitutes the annual report of the ...
Kansas. Legislative Post Audit Committee.
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Annual report : activities of the Legislative Post Audit Committee and the Legislative Division of Post Audit, fiscal year 1979.

, 1979
"A Report to the Kansas Legislature by the Legislative Post Audit Committee, state of Kansas."; "January 16, 1980."Constitutes the annual report of the ...
Kansas. Legislative Post Audit Committee.
core  

Post-discharge tobacco abstinence in a Mumbai hospital after implementation of tobacco cessation counseling: A pragmatic evaluation of the LifeFirst program.

PLoS ONE
BackgroundHospitalization provides a key opportunity to address tobacco use. Few studies have examined cessation treatment in hospitals in low- and middle-income countries (LMIC). We aimed to measure tobacco abstinence among individuals discharged from a
Himanshu A Gupte, Gina R Kruse, Yuchiao Chang, Dinesh Jagiasi, Sultan Pradhan, Nancy A Rigotti   +5 more
doaj   +1 more source

BIM Implementation in Post-War Reconstruction of Ukraine

Buildings
As of January 2024, Ukraine has suffered the extensive destruction of over 160,000 buildings, structures, and infrastructure objects due to the shelling resulting from the ongoing war.
Peter Demian, Tarek M. Hassan, Oleg Kalmykov, Ivan Demianenko, Roman Makarov   +4 more
doaj   +1 more source