Results 71 to 80 of about 11,730,994 (255)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
The Post-implementation Assessment of Advanced Technology Utilization [PDF]
Journal of Competitiveness, 2012 Efficient utilization of advanced manufacturing technology is usually seen as one of the crucial factors in achieving competitiveness on global markets. On the other hand, there are many problems associated with the advanced technology utilization. These
Hynek Josef, Janecek Vaclav
doaj
ERP Post Implementation Review with Process Mining: A Case of Procurement Process
, 2017 This paper promotes the use of process mining and root-cause analysis from BPM field to conduct post implementation review of ERP implementation at business process level.
Mahendrawathi Er +2 more
semanticscholar +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Implementation of Integrated Village NCD Prevention Post (Posbindu) in Senior High School
JHE: Journal of Health Education, 2019 Background: Posbindu PTM s a form of community participation in carrying out activities of early detection and monitoring of PTM risk factors as well as follow-up with the target of healthy people, risk communities and communities with PTM aged from 15 ...
Sri Widodo, Nia Husniah
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
PLoS ONEBackgroundHospitalization provides a key opportunity to address tobacco use. Few studies have examined cessation treatment in hospitals in low- and middle-income countries (LMIC). We aimed to measure tobacco abstinence among individuals discharged from a
Himanshu A Gupte +5 more
doaj +1 more source
Post‐normal conservation science fills the space between research, policy, and implementation
Conservation Science and Practice, 2019 The view that conservation is a linear exchange of knowledge between scientists and practitioners has led to the conceptualization of a “research‐implementation gap”.
Falko T. Buschke +2 more
doaj +1 more source