Results 41 to 50 of about 269,720 (245)

Effect of Muscle Relaxation Technique on Pain, Pruritus and Vital Signs among Patients with Burns [PDF]

Egyptian Journal of Health Care
This study aimed to: assess the effect of muscle relaxation technique on pain, pruritus, and vital signs among patients with burn. Research hypothesis: Muscle relaxation technique will have a positive effect on pain, pruritus and vital signs among ...
Mariana Malaak William, Manal Hussein Nasr, Mona Ndar Ebraheim   +2 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Exploring electronic health record systems implementation in primary health care centres in Saudi Arabia: pre-post implementation

Frontiers in Medicine
BackgroundThe Saudi government has allocated four billion Saudi Riyals (approximately $1,066 million) to establish the National Electronic Health Record (NEHR) and advance its e-health strategy.
Haitham Alzghaibi, Hayley Hutchings
doaj   +1 more source

Introducing a MAP for adherence care in the paediatric cystic fibrosis clinic: a multiple methods implementation study

BMC Health Services Research, 2022
Background People with cystic fibrosis are required to adhere to a burdensome daily treatment regimen. Comprehensive adherence protocols can support more consistent use of adherence interventions and improve treatment adherence rates. This study aimed to
Bianca Richards, Sonya R. Osborne, Megan Simons   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Implementation of early warning system in the clinical teaching unit to reduce unexpected deaths

BMJ Open Quality, 2023
Background Early detection of patients with clinical deterioration admitted to the hospital is critical. The early warning system (EWS) is developed to identify early clinical deterioration.
Rabia Shahid, Tara Swami, Ali Shams, Matthew Mittelstadt, Catherine Guenther, Tiffanie Tse, Hifsa Noor   +6 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Understanding Effective Use in the (Post)-Implementation Phase of Information Systems

, 2017
Organizational information systems (IS) must be used effectively to maximize their benefits for the overall organization. However, their complexity creates significant challenges for conducting the IS project of an implementation in such a way that users are subsequently enabled to use a system effec-tively.
openaire   +3 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source