Results 71 to 80 of about 1,399,508 (279)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Multiphase induction motor drives - a technology status review [PDF]

, 2007
The area of multiphase variable-speed motor drives in general and multiphase induction motor drives in particular has experienced a substantial growth since the beginning of this century.
Abbas, Abolhassani, Andrese, Apsley, Atkinson, Bakhshai, Benatmane, Bendixen, Bojoi, Bojoi, Bojoi, Bojoi, Bojoi, Bojoi, Bojoi, Bojoi, Casadei, Coates, Correa, Correa, Corzine, de Silva, Dente, Duran, E. Levi, Edelson, F. Profumo, Farina, Ferraris, Ferreira, Figureoa, Gataric, Gerada, Golubev, Golubev, Golubev, Gopakumar, Gopakumar, Gritter, H.A. Toliyat, Hadiouche, Hadiouche, Hodge, Hou, Iqbal, Iqbal, Iqbal, Iqbal, Iqbal, Jacobina, Jacobina, Jacobina, Jacobina, Jahns, Jones, Jones, Jones, Jones, Jouanne, Kelly, Kestelyn, Kestelyn, Kestelyn, Kianinezhad, Klingshirn, Levi, Levi, Levi, Levi, Lipo, Locment, Lu, Lyra, Mantero, Mantero, McCoy, Mecrow, Merabtene, Miller, Miranda, Mitcham, Mohapatra, Mohapatra, Mokhtari, Monti, Nelson, Ojo, Oriti, Oudjebour, Parsa, Pereira, Pereira, R. Bojoi, Razik, Ryu, Ryu, S. Williamson, Semail, Semail, Shi, Siala, Silva, Singh, Smith, Smith, Steiner, Sudhoff, Takami, Terrien, Toliyat, Toliyat, Toliyat, Toliyat, Toliyat, Ward, Weh, Williamson, Xu, Xu, Zhao, Zhao, Zheng   +121 more
core   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

THE COMPATIBILITY OF LESSON PLAN USED IN TEACHING ENGLISH TO THE IMPLEMENTATION OF COMPETENCE BASED CURRICULUM AT SMA 2 BLITAR [PDF]

, 2006
The main objective of this study is to investigate the compatibility of the lesson plan used in teaching English to the implementation of Competence Based Curriculum at SMA 2 Blitar.
SETYOWATI, NINING
core  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

A tale of success or complete disaster? : A case study of the post-implementation phase of a new ERP system

, 2023
Enterprise Resource Planning (ERP) systems are considered to be the backbone of many organizations, however, many implemented ERP systems do not live up to the expected potential of organizations. The pre-implementation and implementation phases of ERP projects have received a fair amount of attention in previous literature, but the post ...
Häggblad, Alva, Sundström, Johan
openaire   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

A protocol paper: community engagement interventions for cardiovascular disease prevention in socially disadvantaged populations in the UK: an implementation research study

Global Health Research and Policy, 2020
Background Cardiovascular disorders (CVD) are the single greatest cause of mortality worldwide. In the UK, the National Health Service (NHS) has launched an initiative of health checks over and above current care to tackle CVD.
Papreen Nahar, Harm van Marwijk, Linda Gibson, Geofrey Musinguzi, Sibyl Anthierens, Elizabeth Ford, Stephen A. Bremner, Mark Bowyer, Jean Yves Le Reste, Tholene Sodi, Hilde Bastiaens   +10 more
doaj   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Pain management in Emergency departments. Evaluating the efficacy of an improving method

Emergency Care Journal, 2008
Pain is a very common symptom for patients admitted to Emergency departments (EDs) and its undertreatment represents a widespread problem. A pre-post study on 249 patients (128 pre and 121 in the post phase) assessed the effectiveness of the ...
Dario Gavetti, Simona Frigerio, Paola Di Giulio, Valerio Dimonte   +3 more
doaj   +1 more source