Results 231 to 240 of about 4,915,541 (300)

Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery

Advanced Science, EarlyView.
Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae, Jisun Lee, Jae‐Hun Ahn, Hosam Choi, Huijeong Choi, Jungmin Kim, Minho Kang, Ho Rim Oh, So Hyun Park, Eun Young Oh, Sanghyuk Jeon, Yeeun Lee, Yu‐Sun Lee, Na‐Young Lee, Hee‐Jin Bae, Jina Kwak, Jooil Kim, Nakyung Lee, Beomsun Kang, Ji‐Hye Kim, Eunsaem Song, Daesub Song, Hyunho Yoon, Sang‐Myeong Lee, Hyewon Youn, Kiyoun Lee, Byeong‐Cheol Kang, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Can't help falling in love… with a bot? A mixed-methods analysis of public discourses of AI intimacy and companionship on YouTube. [PDF]

Front Sociol
Shekhar A, Mabaso C.
europepmc   +1 more source

Single‐cell Transcriptome Profiling Reveals Gene Regulatory Networks and Key Genes in the Root Epidermis and Cortical Cells Associated with Early Nodulation in Glycine Max

Advanced Science, EarlyView.
Single‐cell transcriptomics of soybean roots soon after rhizobial inoculation reveals epidermal and cortical cell‐specific programs and gene‐regulatory networks acting in symbiosis establishment. We identify an ethylene‐driven regulatory circuit involving WRKY6.3/6.4 transcription factors targeting select Nod19 genes that promotes infection‐thread ...
Yongbin Zhuang, Yu Geng, Xinyu Guo, Chen Wang, Yongjing Sun, Luqi Liu, Li Liu, QianQian Gao, XinFang Zhu, Hongxiang Cao, Gengshuo Zhang, Yunxia Liu, Guobin Zhang, Baoyin Chen, Jinfei Zhang, Xin Hou, Xiaoming Li, Dajian Zhang   +17 more
wiley   +1 more source

Why are we awake? Algorithmic serendipity and the sociology of sleeplessness. [PDF]

Front Sociol
Bo B, O'Sullivan A, Bariol E, Kucherenko N, Behan M.   +4 more
europepmc   +1 more source

An Artificially Selected Cytokinin‐Pathway Transcription Factor Balances Soybean Yield and Pathogen Resistance

Advanced Science, EarlyView.
A cytokinin pathway transcription factor, RR2b, was artificially selected during soybean domestication and improvement based on its differential transcriptional activity, which correlates with ATT repeat polymorphisms in its promoter. RR2b balances yield and defense by fine‐tuning its expression level and offers a promising target for decoupling trade ...
Qun Ma, Yaqing Chen, Yiwen Gao, Xueting Hu, Qun Yang, Yucheng Liu, Peiyong Xin, Jijun Yan, Jinfang Chu, Lei Li, Zhixi Tian, Bo Ren   +11 more
wiley   +1 more source

Thoughtful Accompaniment in Life's Final Stages: Philosophical Practice as a Complement to Ethics Consultation. [PDF]

Bioethics
Schuchter P, Radinger S, Rieger SV, Wegleitner K.   +3 more
europepmc   +1 more source

In the liminal realm: Qatar's world cup struggle between tradition, modernity, and human rights. [PDF]

Front Sports Act Living
Al-Thani M.
europepmc   +1 more source

Tradition meets modernity: understanding consumer psychology for TCM functional foods in Northern China using integrated structural equation and agent-based modeling. [PDF]

Front Psychol
Zhao Z, Chen L.
europepmc   +1 more source

Introduction to the special issue: Global South histories of madness - new perspectives on mental troubles and psychiatry from Latin America and Africa in the 19th and 20th centuries. [PDF]

Med Hist
Favier I, Tiquet R.
europepmc   +1 more source

"Art as Experience" revisited: Dewey's aesthetic cognition theory in the age of fragmented perception. [PDF]

Front Psychol
Zhang F.
europepmc   +1 more source