Results 181 to 190 of about 24,566 (328)
Advanced Science, EarlyView.A novel chromatin‐labeling probe is developed to investigate chromatin mobility during differentiation. The silicon rhodamine–conjugated dCTP is efficiently delivered into iPSCs and NSCs using a synthetic transporter. Super‐resolution microscopy and single‐particle tracking show decreased chromatin mobility during differentiation.
Maruthi K. Pabba +11 more
wiley +1 more source
Molecular Chain Elongation Mechanism for n‐Caproate Biosynthesis by Megasphaera Hexanoica
Advanced Science, EarlyView.The medium‐chain carboxylate‐producing microbe Megasphaera hexanoica is analyzed through genomics, transcriptomics, and metabolic engineering. The n‐caproate biosynthetic pathway is reconstructed in Escherichia coli, highlighting MhTHL as a key β‐ketothiolase. Structural analysis and mutagenesis reveal that MhTHL has a distinct substrate‐binding pocket,
Byoung Seung Jeon +8 more
wiley +1 more source
NTRU_ SSS: Anew Method Signcryption Post Quantum Cryptography Based on Shamir’s Secret Sharing
, 2023 Asma Ibrahim Hussein +2 more
openalex +1 more source
Isogeny-Based Post-Quantum Cryptography
, 2019 The present thesis focus on one of the post-quantum cryptosystems, in particular, the isogenybased cryptography. Because of its certain properties like the hard problem of computing isogenies between two elliptic curves, it makes it to be one of the few candidates for post-quantum cryptography.
openaire +1 more source
Unveiling Exciton‐Plasmon Polariton Coupling Regions via Polarization‐Enhanced Optical Nanoscopy
Advanced Science, EarlyView.Polarization‐enhanced single‐molecule localization microscopy, utilizing a liquid crystal variable retarder (LCVR), actively controls the on‐off intensity modulation of fluorophores. This active intensity modulation improves the localization accuracy of the point spread function (PSF), enabling high‐contrast super‐resolution imaging with significantly ...
Bin Chan Joo +3 more
wiley +1 more source
Switchbody, an Antigen‐Responsive Enzyme Switch Based on Antibody and Its Working Principle
Advanced Science, EarlyView.This paper presents an antibody‐based enzyme switch, termed a “Switchbody”, which is fused with an enzyme‐derived fragment to the N‐terminus of an antibody. As its working principle, the fused fragment is trapped within the antibody and released upon antigen binding, leading to enzyme reconstitution and a subsequent increase in enzyme activity.
Takanobu Yasuda +10 more
wiley +1 more source
Advanced Science, EarlyView.This study establishes a mandibular asymmetry (MA) mouse model that recapitulates chronic orofacial pain and anxiety comorbidity. Anterior cingulate cortex (ACC) hyperactivation and synaptic dysfunction are identified as central neural mechanisms underlying these pathologies, with chemogenetic inhibition of ACC CaMKII+ neurons effectively reversing ...
Zhaoyichun Zhang +19 more
wiley +1 more source
Molecular Insights into Fungal Glycosylphosphatidylinositol Transamidase Complex
Advanced Science, EarlyView.The glycosylphosphatidylinositol (GPI) biosynthesis pathway is critical for antifungal drug development. This study reports three cryo‐electron microscopy structures of fungal GPI transamidase (GPIT), captured in two substrate‐bound states and a novel dimeric assembly.
Zhengkang Hua +12 more
wiley +1 more source
Secure edge-based IoMT framework for ICU monitoring with TinyML and post-quantum cryptography. [PDF]
Sci RepKhan UH +5 more
europepmc +1 more source