Results 141 to 150 of about 90,964 (263)

The multiple hit model of infantile and epileptic spasms: The 2025 update

open access: yesEpilepsia Open, EarlyView.
Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou   +6 more
wiley   +1 more source

The genetic architecture of epilepsy across molecular mechanisms and clinical heterogeneity

open access: yesEpilepsia Open, EarlyView.
Abstract Epilepsy comprises a highly heterogeneous group of neurological disorders unified by a persistent predisposition to recurrent seizures, yet driven by remarkably diverse genetic, molecular, and network‐level mechanisms. Advances in genomic technologies have revealed that epilepsy arises from a multilayered genetic architecture encompassing rare
Mohammad Reza Seyedtaghia   +4 more
wiley   +1 more source

Phenotype‐guided etiologic workup in a prospective cohort of 144 adults with developmental and epileptic encephalopathy

open access: yesEpilepsia Open, EarlyView.
Abstract Objectives Adults with developmental and epileptic encephalopathies (DEEs) often enter adult neurology care without etiologic clarification because of incomplete transition from pediatric services, outdated investigations, and attenuation of childhood electro‐clinical features over time.
Giuseppe d’Orsi   +10 more
wiley   +1 more source

Association of acute-phase plasma pTau217 levels with long-term post-stroke cognitive impairment. [PDF]

open access: yesFront Aging Neurosci
Macías M   +15 more
europepmc   +1 more source

Impact of vigabatrin on risk of relapse of infantile spasms

open access: yesEpilepsia Open, EarlyView.
Abstract Objective Vigabatrin is an effective treatment for infantile epileptic spasms syndrome (IESS), but relapse remains a clinical challenge. The ideal dose and duration of treatment after response are unknown. We set out to identify treatment‐related predictors of IESS relapse after initial vigabatrin response. Methods We conducted a retrospective
Yaretson I. Carmenate   +5 more
wiley   +1 more source

EEG CONNECT: A proposed reporting checklist for EEG‐based connectivity studies in clinical epilepsy research

open access: yesEpilepsia Open, EarlyView.
Abstract EEG‐based connectivity analysis has emerged as a promising approach for investigating brain network dynamics in clinical epilepsy research. However, the diversity of analytical approaches, preprocessing pipelines, and reporting practices poses challenges to reproducibility and clinical translation.
Naoto Kuroda   +6 more
wiley   +1 more source

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