Results 121 to 130 of about 348,774 (324)

Post-transcriptional and post-translational regulations of drought and heat response in plants: a spider’s web of mechanisms [PDF]

, 2015
Drought and heat tolerance are complex quantitative traits. Moreover, the adaptive significance of some stress-related traits is more related to plant survival than to agronomic performance.
Anna M. Mastrangelo, Cristina Crosatti, Davide Guerra, Elisabetta Mazzucotelli, Erica Mica, Hamid H. Khoshro   +5 more
core   +2 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Androgen blockage impairs proliferation and function of Sertoli cells via Wee1 and Lfng

Cell Communication and Signaling
Background Androgens are essential hormones for testicular development and the maintenance of male fertility. Environmental factors, stress, aging, and psychological conditions can disrupt androgen production, impacting the androgen signaling pathway and
Wenhui Zhai, Hairui Tian, Xuemei Liang, Yunqiang Wu, Jian Wen, Zhipeng Liu, Xiaodong Zhao, Li Tao, Kang Zou   +8 more
doaj   +1 more source

Post-transcriptional modification of m⁶A methylase METTL3 regulates ERK-induced androgen-deprived treatment resistance prostate cancer. [PDF]

Cell Death Dis, 2023
Li Y, Zhu S, Chen Y, Ma Q, Kan D, Yu W, Zhang B, Chen X, Wei W, Shao Y, Wang K, Zhang M, Deng S, Niu Y, Shang Z.   +14 more
europepmc   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Subgenome Dominance in Allotetraploid Actinidia valvata Regulates RNA m6A Modification for Waterlogging Tolerance

Advanced Science
Polyploidization is a major driving force for evolutionary innovation and environmental adaptation in plants and is notably prevalent in kiwifruits.
Xiaoli Hu, Changbin Xu, Xiaolan Li, Lin Li, Yu Bao, Miaofeng Gu, Xinyi Li, Liuqing Huo, Jinli Gong, Xiaolong Li, Minhui Wang, Kai Xu, Xueren Yin, Zhangjun Fei, Xuepeng Sun   +14 more
doaj   +1 more source

Post-Transcriptional Modification by Alternative Splicing and Pathogenic Splicing Variants in Cardiovascular Development and Congenital Heart Defects. [PDF]

Int J Mol Sci, 2023
Mehta Z, Touma M.
europepmc   +1 more source

Post-Transcriptional Modifications Explain the Overexpression of CCND2 in Multiple Myeloma

Blood, 2014
Abstract CCND2 is highly expressed in most of multiple myeloma (MM) samples without CCND1 or CCND3 overexpression. D-type cyclins are highly homologous proteins and there is a growing body of evidence that the functions of the D cyclins are mostly exchangeable. During mouse development, the three D-type cyclins are expressed following an
Elizabeta A. Rojas, Norma C. Gutiérrez, Luis A. Corchete, Ana A. Martín, Rocío Corral, Fernando Escalante, Carolina Vicente-Dueñas, Irena Misiewicz-Krzeminska, Irena Misiewicz-Krzeminska, Patryk Krzemiński, Dalia Quwaider, Isidro Sánchez-García, María Eugenia Sarasquete, Juan Luis García, Ramón García-Sanz, Abelardo Bárez, Jesús F. San Miguel, Katarzyna Wiktorska   +17 more
openaire   +2 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source