Results 291 to 300 of about 348,774 (324)

Epigenetics in neonatal necrotizing enterocolitis: current understanding and the potential involvement of m6A modification. [PDF]

Front Pediatr
Chen Y, Chen Y.
europepmc   +1 more source

Engineering Extracellular Microenvironments: The Impact of Fibrous Materials on Cell Behavior

Advanced Healthcare Materials, EarlyView.
Fibrous structures are key elements of the native extracellular matrix and crucial for directing cell behavior. This review discusses how fiber properties such as composition, diameter, and alignment affect cell responses in 2D and 3D systems. Strategies for integrating fibrous cues into engineered tissues are highlighted, and future directions for ...
Zan Lamberger, Gregor Lang
wiley   +1 more source

TRIM35, a novel DNA-binding protein, epigenetically modifies H3 to promote HSPA6 transcription and suppress breast cancer progression. [PDF]

Cell Death Discov
Jing X, Li F, Zhou J, Zhang J, Cao L, Guo C, Li Q, Peng H, Jiang Q, Wang X, Chen Y, Ding J, Tong D, Zhao Z, Huang C.   +14 more
europepmc   +1 more source

At the Pointy End of Mechanobiology: AFM for Transient Biomechanical Analysis

Advanced Healthcare Materials, EarlyView.
Stem cell mechanosensitivity governs lineage commitment through mechanotransduction, but capturing these transient changes in living cells remains challenging. Advanced atomic force microscopy enables high‐resolution analysis of mechanical properties, real‐time protein distribution, and gene expression, offering fresh insights into cell‐environment ...
Kaiwen Zhang, Chayla L. Reeves, Mehrnoosh Moghaddar, Kate E. Fox, Aaron Elbourne, Amy Gelmi   +5 more
wiley   +1 more source

Silencing Myostatin Using In Vivo Self‐Assembled siRNA Protects Against Cancer‐ and Dexamethasone‐Induced Muscle Atrophy

Advanced Healthcare Materials, EarlyView.
This study reports an in vivo self‐assembled siRNA strategy that enables the liver to generate small extracellular vesicles (sEVs) tagged with a muscle‐targeting peptide (MSP) and naturally loaded with myostatin (MSTN)‐siRNA. These MSP‐tagged sEVs are systemically delivered to skeletal muscle, efficiently silence MSTN, promote muscle hypertrophy, and ...
Xin Yin, Azhar Anwar, Jiehao Chen, Qinghao Sun, Likun Zhou, Jie Tang, Jingwei Guo, Linbo Yan, Yongci Chen, Feng Yin, Chen‐Yu Zhang, Zigang Li, Jizheng Ma, Liyuan Sheng, Xi Chen   +14 more
wiley   +1 more source

Synergistic effect of nucleoside modification and ionizable lipid composition on translation and immune responses to mRNA vaccines. [PDF]

NPJ Vaccines
Danz H, Dauner A, Sharma S, Babiceanu M, Clark N, Ontiveros RJ, Amezquita R, Zhilin-Roth A, Reyes E, Khoo C, Gilbert K, Nadkarni J, Chaudhary O, Lee C, Kume A, Bahadoran A, Motwani M, Lu B, Zong W, Kettring A, Shumate A, Karve S, Dias A, Wu M, Gu X, Yan Y, Anderson DG, Schanen B, Chivukula S, DeRosa F.   +29 more
europepmc   +1 more source

Guides for Developing Hundreds of Novel Chiral MXenes and MBenes Nanosheets/Quantum Dots for Next‐Generation Chiral Engineered Biomaterials Applications

Advanced Healthcare Materials, EarlyView.
The emerging field of MXene/MBene materials has progressed rapidly, advancing diverse research fields, including biomedical engineering, biomedicine, agriculture, and the environment. This nanobiotechnology can tackle longstanding challenges in these areas.
Alireza Rafieerad, Ahmad Amiri
wiley   +1 more source

PUS7-dependent Ψ reshapes specific synaptic gene exons to facilitate fear extinction memory formation. [PDF]

Mol Brain
Liu R, Dong Y, Gao Z, Shi J, Xu Z, Liu J, Luo G, Ye S, Zhang F, Xu H, Li X, Liu S, Wei W.   +12 more
europepmc   +1 more source

Multiscale Hybrid Surface Topographies Orchestrate Immune Regulation, Antibacterial Defense, and Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
Hybrid wrinkled topographies coordinate immune, tissue, and bacterial interactions. The surfaces promote osteointegration, tune macrophage polarization, and inhibit biofilm formation, highlighting a multifunctional strategy for next‐generation implant design.
Mohammad Asadi Tokmedash, Jacob Robins, J. Scott VanEpps, Minji Kim, Jouha Min   +4 more
wiley   +1 more source

Advances in RNA modification in myocardial fibrosis (Review). [PDF]

Int J Mol Med
Wu X, Wang R, Chen X, Wang K.
europepmc   +1 more source