Unraveling the signaling pathways of plant cold stress: current insights and future directions. [PDF]
Peng C, Hua W, Liu J.
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Regulation of <i>NR4A2</i> Gene Expression and Its Importance in Neurodegenerative and Psychiatric Diseases. [PDF]
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The Dynamic Regulation of Daxx-Mediated Transcriptional Inhibition by SUMO and PML NBs. [PDF]
Gao J, Liu T, Yang D, Tuo Q.
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Decoding Encoded Cravings: Epigenetic Drivers of Addiction. [PDF]
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Crosstalk between lactylation and RNA modifications in tumorigenesis: mechanisms and therapeutic implications. [PDF]
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RNA post-transcriptional modification speaks to chromatin
Nature Genetics, 2020The role of N6-methyladenosine (m6A) is still not fully understood. Two new studies advance understanding of this RNA modification. One shows that m6A modification of nascent messenger RNA promotes transcription by recruiting the histone H3 K9 demethylase KDM3B. Another study identifies genetic variants that affect m6A deposition and human disease.
Dalen Chan, Pedro J. Batista
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Post-transcriptional Modifications Modulate rRNA Structure and Ligand Interactions [PDF]
Post-transcriptional modifications play important roles in modulating the functions of RNA species. The presence of modifications in RNA may directly alter its interactions with binding partners or cause structural changes that indirectly affect ligand recognition.
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Traces of post-transcriptional RNA modifications in deep sequencing data
Biological Chemistry, 2011Abstract Many aspects of the RNA maturation leave traces in RNA sequencing data in the form of deviations from the reference genomic DNA. This includes, in particular, genomically non-encoded nucleotides and chemical modifications. The latter leave their signatures in the form of mismatches and conspicuous patterns of sequencing reads ...
Peter F. Stadler +3 more
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Small nucleolar RNAs and RNA-guided post-transcriptional modification
Essays in Biochemistry, 2013snoRNAs (small nucleolar RNAs) constitute one of the largest and best-studied classes of non-coding RNAs that confer enzymatic specificity. With associated proteins, these snoRNAs form ribonucleoprotein complexes that can direct 2′-O-methylation or pseudouridylation of target non-coding RNAs.
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Minimal post-transcriptional modification of yeast mitochondrial ribosomal RNA
Journal of Molecular Biology, 1975Yeast mitochondrial ribosomal RNAs (21 S and 15 S) † have been analysed for methylated residues and pseudo-uridine content. Analysis of methyl-3H-labelled nucleosides in 21 S rRNA shows the presence of only two methylated residues with a molar yield of approximately one; they are presumably ribose methylated, because in 32PO4-labelled 21 S RNA two ...
La Grivell, I. Klein, J. Klootwijk
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