Results 301 to 310 of about 348,774 (324)

Regulation of <i>NR4A2</i> Gene Expression and Its Importance in Neurodegenerative and Psychiatric Diseases. [PDF]

open access: yesInt J Mol Sci
Ruiz-Sánchez E   +9 more
europepmc   +1 more source

Decoding Encoded Cravings: Epigenetic Drivers of Addiction. [PDF]

open access: yesBrain Sci
Hediyal TA   +5 more
europepmc   +1 more source

Crosstalk between lactylation and RNA modifications in tumorigenesis: mechanisms and therapeutic implications. [PDF]

open access: yesBiomark Res
Liu S   +9 more
europepmc   +1 more source
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RNA post-transcriptional modification speaks to chromatin

Nature Genetics, 2020
The role of N6-methyladenosine (m6A) is still not fully understood. Two new studies advance understanding of this RNA modification. One shows that m6A modification of nascent messenger RNA promotes transcription by recruiting the histone H3 K9 demethylase KDM3B. Another study identifies genetic variants that affect m6A deposition and human disease.
Dalen Chan, Pedro J. Batista
openaire   +2 more sources

Post-transcriptional Modifications Modulate rRNA Structure and Ligand Interactions [PDF]

open access: possibleAccounts of Chemical Research, 2016
Post-transcriptional modifications play important roles in modulating the functions of RNA species. The presence of modifications in RNA may directly alter its interactions with binding partners or cause structural changes that indirectly affect ligand recognition.
Jun Jiang   +2 more
openaire   +2 more sources

Traces of post-transcriptional RNA modifications in deep sequencing data

Biological Chemistry, 2011
Abstract Many aspects of the RNA maturation leave traces in RNA sequencing data in the form of deviations from the reference genomic DNA. This includes, in particular, genomically non-encoded nucleotides and chemical modifications. The latter leave their signatures in the form of mismatches and conspicuous patterns of sequencing reads ...
Peter F. Stadler   +3 more
openaire   +4 more sources

Small nucleolar RNAs and RNA-guided post-transcriptional modification

Essays in Biochemistry, 2013
snoRNAs (small nucleolar RNAs) constitute one of the largest and best-studied classes of non-coding RNAs that confer enzymatic specificity. With associated proteins, these snoRNAs form ribonucleoprotein complexes that can direct 2′-O-methylation or pseudouridylation of target non-coding RNAs.
Lauren M. Lui, Todd M. Lowe
openaire   +3 more sources

Minimal post-transcriptional modification of yeast mitochondrial ribosomal RNA

Journal of Molecular Biology, 1975
Yeast mitochondrial ribosomal RNAs (21 S and 15 S) † have been analysed for methylated residues and pseudo-uridine content. Analysis of methyl-3H-labelled nucleosides in 21 S rRNA shows the presence of only two methylated residues with a molar yield of approximately one; they are presumably ribose methylated, because in 32PO4-labelled 21 S RNA two ...
La Grivell, I. Klein, J. Klootwijk
openaire   +3 more sources

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