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Post-transcriptional Modifications Modulate rRNA Structure and Ligand Interactions
Accounts of Chemical Research, 2016Post-transcriptional modifications play important roles in modulating the functions of RNA species. The presence of modifications in RNA may directly alter its interactions with binding partners or cause structural changes that indirectly affect ligand recognition.
Jun, Jiang +2 more
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RNA Post-Transcriptional Modification Mapping Data Analysis Using RNA Framework
2021RNA post-transcriptional modifications (PTMs) are progressively gaining relevance in the study of coding-independent functions of RNA. RNA PTMs act as dynamic regulators of several aspects of the RNA physiology, from translation to half-life. Rising interest is supported by the advance of high-throughput techniques enabling the detection of these ...
Manfredonia, Ilaria, Incarnato, Danny
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Traces of post-transcriptional RNA modifications in deep sequencing data
Biological Chemistry, 2011Abstract Many aspects of the RNA maturation leave traces in RNA sequencing data in the form of deviations from the reference genomic DNA. This includes, in particular, genomically non-encoded nucleotides and chemical modifications. The latter leave their signatures in the form of mismatches and conspicuous patterns of sequencing reads ...
Findeiss, Sven +3 more
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[Post-transcriptional protein modification of Gata4].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2013Gata4 is an important transcription factor in heart development. Gata4 post-transcriptional protein modification regulates transcriptional activity and DNA binding, which in turn affects expression of downstream genes and transcription factors, differentiation of embryonic stem cells and cardiogenesis.
Li-Wei, Yu, Yong-Hao, Gui
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The impact of epitranscriptomic marks on post-transcriptional regulation in plants.
Briefings in Functional Genomics, 2020Ribonucleotides within the various RNA molecules in eukaryotes are marked with more than 160 distinct covalent chemical modifications. These modifications include those that occur internally in messenger RNA (mRNA) molecules such as N6-methyladenosine ...
Xiang Yu, Bishwas Sharma, B. Gregory
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Gonadotropin Receptors: Role of Post-translational Modifications and Post-transcriptional Regulation
Endocrine, 2005This review focuses on the post-translational modifications of LH and FSH receptors and recent studies on the regulation of LH receptor expression mediated by an RNA binding protein. Both LH and FSH receptors undergo extensive post-translational modifications.
K M J, Menon +2 more
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RNA Processing and Other Post-Transcriptional Modifications
1982RNA molecules play a central part in cell metabolism, either by directing the synthesis of proteins or functioning as essential components of the proteinsynthesising machinery. A detailed knowledge of their structure and metabolism is, therefore, an essential pre-requisite for an understanding of the control of protein synthesis.
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Post-Transcriptional Modifications of Plant Small RNAs
2011Generally, small RNAs are generated template dependent by RNA polymerases or RNA dependent RNA polymerases with the transcription template being either DNA or RNA. Following transcription, small RNAs in plants undergo processing by Dicer-like RNase III type endonucleases to define their mature 5′ and 3′ termini. Part of the maturation process of small
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Post-transcriptional modification of globin RNA.
Texas reports on biology and medicine, 1982During the last three years, significant progress has been made in the characterization of the structure of globin RNA precursors and the steps involved in their modifications to mature mRNA. Aside from the coding sequence, IVSs in RNA precursors have a critical function in the formation of mature mRNA.
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Post-transcriptional and Post-translational Modifications Controlling Cold Response
2013The molecular response of plants to cold stresses has been often considered as a complex process mainly based on the modulation of transcriptional activity of stress-related genes. Nevertheless, recent findings indicate new layers of regulation. Post-transcriptional mechanisms based on alternative splicing and RNA processing, as well as RNA silencing ...
Elisabetta Mazzucotelli +4 more
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