Results 131 to 140 of about 364,184 (216)
Advanced Science, EarlyView.This study reports a neutrophil membrane‐encapsulated Pd/hCeO2 nanozyme (PCN) for targeted treatment of perioperative neurocognitive disorders (PND) in aged mice. PCN inhibits glycolysis‐driven microglial activation and neuroinflammation, improves mitochondrial respiration, and maintains blood‐brain barrier integrity and synaptic function, ultimately ...
Lili Huang +17 more
wiley +1 more source
Advanced Science, EarlyView.Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong +13 more
wiley +1 more source
Advanced Science, EarlyView.An immunomagnetic‐MXene bifunctional probe integrated with THz metamaterials enables ultrasensitive and specific detection of pancreatic cancer‐derived exosomes. Dual biomarker recognition ensures high specificity, while MXene signal amplification achieves a detection limit of 647 particles mL−1.
Weidong Jin +8 more
wiley +1 more source
Post-Traumatic Stress Symptoms and Dissociation in Emergency Medical Service Personnel. [PDF]
Healthcare (Basel)Tsruya R, Shadach E, Shelef L.
europepmc +1 more source
Advanced Science, EarlyView.Diabetic bone defects remain a critical clinical challenge. A 3D‐printed BCPG‐MF@Y scaffold, embedding Yoda1‐functionalized manganese dioxide‐ferritin nanozymes, scavenges mtROS, suppresses the cGAS–STING pathway, and reverses cellular senescence, while Yoda1 activates Piezo1 to direct BMSCs fate to synergistically reprogram the osteoimmune ...
Qing‐Song Deng +16 more
wiley +1 more source
A rare cause of post-traumatic low back pain: Lumbar Morel-Lavallée lesion in a collegiate athlete - A case report. [PDF]
Interv Pain MedThomas R, Huynh L.
europepmc +1 more source
Lactate Signal: Modulator of Cellular Energy Production and Anabolism
Advanced Science, EarlyView.Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley +1 more source
Cellular Mechanisms Enabling Mitochondria Transfer and Transplantation
Advanced Science, EarlyView.Mitochondrial transfer and transplantation (mitoTT) is examined as a multistep process governed by distinct transfer routes and post‐transfer checkpoints. Mechanisms controlling mitochondrial uptake, network integration, cristae remodeling, mtDNA maintenance, immune sensing, and quality control are highlighted, revealing key biological and ...
F. Seyma Gokdemir +3 more
wiley +1 more source