Results 101 to 110 of about 9,791,095 (282)

Mesoporous Catalytic‐Adsorptive Nanoregulator Orchestrates Biofilm eDNA/LPS Disassembly and TLR9/TLR4 Immune Reprogramming to Resolve Diabetic Foot Infections

Advanced Science, EarlyView.
Chronic diabetic wounds are hindered by a “dual trap” of biofilm resistance and hyperinflammation. A mesoporous catalytic‐adsorptive nano‐regulator is developed to dismantle this barrier through simultaneous eDNA degradation and LPS sequestration. By silencing TLR4/9‐mediated signaling, the platform clears resilient pathogens and reprograms the immune ...
Junfeng Song, Yang Song, Xirui Huang, Xingjin Li, Lifei Gao, Yixiang Wang, Tianbao Zhu, Xiaomin Li, Shuai Wang, Tiancong Zhao, Dongyuan Zhao   +10 more
wiley   +1 more source

Post-traumatic growth and influencing factors of parents with children with Duchenne muscular dystrophy: a cross-sectional survey study

Italian Journal of Pediatrics
Background The aim of the study was to identify the post-traumatic growth status and influencing factors of parents with children with Duchenne muscular dystrophy (DMD). Methods We adopted a cross-section survey study. Between February and December 2022,
Li Xu, Meili Liu, Yuewei Chen, Liwen Wu, Siyi Gan, Jianhui Xie, Jos M. Latour   +6 more
doaj   +1 more source

Palmitoylation of PSD‐95 Orchestrates Learning‐Dependent Metaplasticity in the Amygdala and Fear Memory

Advanced Science, EarlyView.
This study reveals that fear learning specifically triggers PICK1/DHHC2‐dependent palmitoylation of PSD‐95 in the lateral amygdala. Fear conditioning induces the dissociation of DHHC5 from PSD‐95 and the association of PSD‐95 with DHHC2. DHHC2‐mediated palmitoylation of PSD‐95 is required for synaptic transmission and underlies fear learning–induced ...
Zu‐Cheng Shen, Yu‐Xuan Weng, Zhi‐Xuan Xia, Yue‐Ling Zhao, Qian‐Qian Ding, Si‐Ying Wang, Ting Cao, Xuan‐Ying Chen, Wu‐Cheng Tao, Shen Lin, Zhou Chen, Yi‐Xiao Luo   +11 more
wiley   +1 more source

ROS‐Targeted Nanomotor Therapy in OA: Cartilage Protection and Pain Relief

Advanced Science, EarlyView.
ROS‐responsive NM@MET nanomotors utilize elevated ROS in osteoarthritic joints to promote deep penetration into cartilage and synovium and enable sustained metformin release. By scavenging ROS, regulating NRF2/KEAP1 signaling, protecting chondrocytes, suppressing synovial inflammation, and attenuating nociceptive signaling, NM@MET alleviates pain and ...
Meng Zheng, Changyu Liu, Qin Xia, Arndt F. Schilling, Jiawei Jiang, Renpeng Peng, Zixing Shu, Tian Ma, Danni Luo, Yaoyu Zhang, Yibo Fan, Xuyuan Zhang, Song Li, Kai Wang, Wentao Ke, Yuan Xiong, Yuanli Zhu, Fangzhi Mou, Jun Xiao, Hao Zhu   +19 more
wiley   +1 more source

Post-Traumatic Growth, Psychological Well-Being, and Distress

, 2015
The process of adaptation to stressful life events can be different from person to person, leading to distress but also to positive changes, subsumed under the rubric of post-traumatic growth (PTG).
ALBIERI, ELISA, Chiara Ruini, Francesca Vescovelli, Elisa Albieri, RUINI, CHIARA, VESCOVELLI, FRANCESCA   +5 more
core   +1 more source

Post-traumatic growth in liver cirrhosis patients: a cross-sectional study on the roles of psychological resilience and fear of progression based on the stress-coping theory

Frontiers in Psychology
ObjectiveTo investigate the current status of post-traumatic growth in patients with liver cirrhosis, analyze the influencing factors of post-traumatic growth, and provide a theoretical basis for the development of targeted intervention measures.MethodsA
Yanyan Wang, Fei Kong, Qing Zhang, Qianqian Wang, Lijuan Yang   +4 more
doaj   +1 more source

Single‐Cell Profiling Identifies SLC2A5‐Mediated Fructose Metabolism as a Vulnerability in Primary CNS Lymphoma

Advanced Science, EarlyView.
Glucose deprivation in the primary CNS lymphoma (PCNSL) tumor microenvironment drives SLC2A5 (encoding GLUT5)‐dependent fructose metabolism in tumor cells, while hypoxia induces HIF‐mediated SLC2A5 expression in tumor‐supportive macrophages, revealing SLC2A5‐driven fructose utilization as a shared and targetable metabolic vulnerability across malignant
Qiaoli Wu, Qianru Zhang, Wenqiang Yan, Lu Sun, Yiran Cui, Bolin Liu, Guoqing Han, Feng Zhang, Ke Pu, Mingchao Zhang, Xiaobing Zhang, Qingguo Li, Gang An, Yuxuan Liu   +13 more
wiley   +1 more source

Vicarious post-traumatic growth in Chinese oncology nurses: A cross-sectional study.

PLoS ONE
In the traditional Chinese culture, vicarious trauma poses a significant threat to oncology nurses who are frequently exposed to death and illness. This exposure can undermine both the physical and mental health of these nurses, potentially affecting ...
Jinghan Xu, Dandan Chen, Blandine Lucrece Jongo Fouelefack, Yunxian Zhou   +3 more
doaj   +1 more source

Relationships between body image, dyadic coping and post-traumatic growth in breast cancer patients: a cross-sectional study

Frontiers in Psychology
BackgroundThe diagnosis and treatment of cancer triggers not only a negative psychological response for the patient, but also a positive psychological outcome.
Yuan Wang, Shan Wang, Ling Tong, Jiaru Zhuang, Yihan Xu, Yibo Wu, Ling Chen   +6 more
doaj   +1 more source

MAM‐Localized MANF Counteracts Microinflammatory Stress to Attenuate Mitochondrial Dysfunction and Cataractogenesis in High Myopia

Advanced Science, EarlyView.
Chronic microinflammation in high myopia suppresses MANF in lens epithelial cells. MANF normally resides within MAMs and promotes ubiquitin‐mediated degradation of the ER Ca2+ pump SERCA2. MANF loss causes pathological SERCA2 accumulation, MAM hyperassembly, and disrupted ER‐to‐mitochondria Ca2+ transfer, leading to mitochondrial failure, oxidative ...
Xin Liu, Hao Li, Ching Kang, Dongling Guo, Shuyu Liu, Jiaqi Meng, Zhiqian Huang, Yu Du, Xiangjia Zhu   +8 more
wiley   +1 more source