Results 41 to 50 of about 26,337 (144)

A Reappraisal of the U.S. Clinical Trials of Post-Treatment Lyme Disease Syndrome [PDF]

The Open Neurology Journal, 2012
Four federally funded randomized placebo-controlled treatment trials of post-treatment Lyme syndrome in the United States have been conducted. Most international treatment guidelines summarize these trials as having shown no acute or sustained benefit to repeated antibiotic therapy.
Fallon, Brian A., Petkova, Eva, Keilp, John G., Britton, Carolyn Barley   +3 more
openaire   +3 more sources

Role of glutathionylation in infection and inflammation [PDF]

, 2019
Glutathionylation, that is, the formation of mixed disulfides between protein cysteines and glutathione (GSH) cysteines, is a reversible post-translational modification catalyzed by dierent cellular oxidoreductases, by which the redox state of the cell
Baldelli, S., Checconi, P., Ciriolo, M. R., Limongi, D., Nencioni, L., Palamara, A. T.   +5 more
core   +1 more source

Efficacy and Safety of Guselkumab in Participants With Active Psoriatic Arthritis After Inadequate Response to One Prior Tumor Necrosis Factor Inhibitor: Week‐24 Results of a Phase 3, Randomized, Placebo‐Controlled Study

Arthritis &Rheumatology, EarlyView.
Objective To evaluate the efficacy and safety of guselkumab, an interleukin‐23p19 subunit inhibitor, in participants with active psoriatic arthritis (PsA) and inadequate response (inadequate efficacy and/or intolerance) to one prior tumor necrosis factor (TNF) inhibitor.
Alexis Ogdie, Joseph F. Merola, Philip J. Mease, Christopher T. Ritchlin, Jose U. Scher, Kimberly Parnell Lafferty, Daphne Chan, Soumya D. Chakravarty, Wayne Langholff, Yanli Wang, Jie Shao, Yevgeniy Krol, Alice B. Gottlieb   +12 more
wiley   +1 more source

Attention‐deficit hyperactivity disorder in children and young persons during the COVID‐19 pandemic. A temporal trends analysis of electronic heath records in Greater Manchester, England

JCPP Advances, EarlyView.
Abstract Background The incidence of attention‐deficit hyperactivity disorder (ADHD) in children and young people has increased in recent years. Disease frequency varies according to sociodemographic characteristics. There are seasonal patterns in ADHD diagnosis and prescribing with rates falling during school holidays.
Louise Hussey, Evangelos Kontopantelis, Pearl L. H. Mok, Darren M. Ashcroft, Shruti Garg, Carolyn A. Chew‐Graham, Karina Lovell, Roger T. Webb   +7 more
wiley   +1 more source

Education on Tickborne Diseases and Prevention Strategies [PDF]

, 2017
Research suggests that around 300,000 people are diagnosed with Lyme disease each year and that around one billion dollars is spent on healthcare for Lyme disease alone.
Bernard, Christopher
core   +1 more source

Science, Politics, and Values: The Politicization of Professional Practice Guidelines [PDF]

, 2009
The Connecticut Attorney General’s recent allegations that the Infectious Disease Society of America violated antitrust law through its treatment guidelines for Lyme disease were neither based in sound science or appropriate legal judgment.
Gostin, Lawrence O., Kraemer, John D.
core   +1 more source

‘Reservoir dogs’: The emerging zoonotic risk associated with European dog imports to the UK

Veterinary Record, EarlyView.
Abstract Background The movement of dogs from continental Europe to the UK poses a growing public health threat due to the associated risk of disease incursions. Current legislation is insufficient to address the risks and pre‐import control measures are focused only on rabies virus and the fox tapeworm Echinococcus multilocularis. Methods We conducted
Poppy Simonson, Tapan Bhattacharyya, Michael A. Miles   +2 more
wiley   +1 more source

Severity of chronic Lyme disease compared to other chronic conditions: a quality of life survey [PDF]

, 2014
Overview. The Centers for Disease Control and Prevention (CDC) health-related quality of life (HRQoL) indicators are widely used in the general population to determine the burden of disease, identify health needs, and direct public health policy.
Aslan, Aucott, Aucott, Bayliss, Becker, Bhinder, Boscardin, Burns, Cairns, Cameron, Centers for Disease Control and Prevention, Chandra, Cook, DeSalvo, Donkin, Fallon, Hoge, Institute of Medicine, Johnson, Klempner, Lackner, Liu, Logigian, Moriarty, Rangnekar, Richardson, Schutzer, Shadick, Smith, Steere, Stricker, Toossi, van Gelder, Wolfe, Yazdany   +34 more
core   +1 more source

Vectors and Vector‐Borne Diseases: Biology, Epidemiology and Integrated Control Strategies

Journal of Applied Entomology, EarlyView.
ABSTRACT Vector‐Borne Diseases (VBDs), transmitted by arthropods such as mosquitoes, ticks, fleas and sandflies, represent a significant threat to global health. These diseases can be caused by a variety of pathogens, including bacteria, viruses, protozoa, and helminths.
Roberta Rinaldi, Carmen Scieuzo, Federica De Stefano, Luca Masucci, Patrizia Falabella   +4 more
wiley   +1 more source

Cellular immune response of Amblyomma sculptum and Amblyomma americanum to entomopathogenic fungi: Implications for biological tick control

Medical and Veterinary Entomology, EarlyView.
Amblyomma sculptum showed a plasmatocyte‐dominant haemocyte profile. Beauveria bassiana increased plasmatocytes and reduced granulocytes, whereas Metarhizium robertsii did not cause significant changes. Amblyomma americanum showed a granulocyte‐dominant haemocyte profile. Beauveria bassiana reduced total haemocytes and granulocytes. B.
Cárita de Souza Ribeiro‐Silva, Valesca Henrique Lima, Salorrane Miranda N. Pinto, Gustavo Felizardo S. Sandes, Victor Hugo Ribeiro Costa, Albert Mulenga, Adela S. Oliva Chavez, Éverton Kort Kamp Fernandes   +7 more
wiley   +1 more source