Results 51 to 60 of about 105,007 (295)
What Rises Above the White Noise: the Possibility of Hearing Truth in a Post-truth World [PDF]
, 2017 This installation in a valley in the UK’s Lake District National Park taps into the idea of communication, the problem of apparent fact and post-truth, and which voices are being heard when it comes to standing up for the environment.
Fraser, Harriet, Fraser, Rob
core +1 more source
Humanitarian communication in a post-truth world [PDF]
, 2019 When people look online for information about humanitarian crises, they increasingly encounter media contentthat blurs the line between reality and fiction.
Bunce, M.
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
The politics of post-truth [PDF]
, 2017 Every book is imbued with the name of God, and we have anagrammed all books in history, without praying […]. What our lips said, our cells have learnt. What have my cells done? They have invented a different Plan, and now they are going their way.
Orsi, Roberto
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Leadership in a post-truth era : a new narrative disorder? [PDF]
, 2019 This essay, and the speical issue it introduces, seeks to explore leadership in a post-truth age, focusing in particular on the types of narratives and counter-narratives that characterize it and at times dominate it.
Foroughi, Hamid +2 more
core +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Rethinking Populism in the Digital Age: Social Networks, Political Affects and Post-Truth Democracies [PDF]
, 2017 Although populism is not a new phenomena, its rise in the aftermath of the financial crisis presents some novelties that are worth exploring. Mostly, they refer to the transformation of the public sphere in the digital era, which has changed how ...
Arias-Maldonado, Manuel Jesus
core