Results 81 to 90 of about 40,053 (304)

Housing in the Northwest Territories: the Post-War Vision [PDF]

open access: yesUrban History Review, 1995
The delivery of housing programs in the Northwest Territories in the post—World War II era was part and parcel of government's newly defined northern mandate. Often described as the "northern vision", the northern mandate was a wide ranging initiative that provided for government-orchestrated, northern expansion.
openaire   +2 more sources

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao   +6 more
wiley   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan   +9 more
wiley   +1 more source

CAR T‐Cell Therapy in Neurology: A Scoping Review of Neuro‐Oncology, Autoimmune Diseases & Neurotoxicity

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi   +5 more
wiley   +1 more source

Postwar reconstruction and the questions of popular housing provision, 1939-1951 : the debates and implementation of policy, with particular reference to Coventry and Portsmouth [PDF]

open access: yes
The existing historiography has done much to highlight the significance of the 1940s in the evolution of social policy in Great Britain. This thesis is an attempt to assess whether there was a new departure in popular housing provision in this period.
Tsubaki, Tatsuya
core  

Association Between Motor Pathway Damage and Motor Deficit in Upper and Lower Limb in People With MS

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Corticospinal tract damage is common in people with MS, but the degree of clinical symptoms varies. We hypothesize that corticospinal tract lesions are more extensive and severe in people with MS with motor impairments in both upper and lower limbs.
Mathilde Liffran   +13 more
wiley   +1 more source

Social policy and housing: reflections of social values

open access: yes, 2010
This thesis set out to find the correlation between social values and standards in social housing in two major milestones in the developments in state-provided housing.
Manoochehri, J.
core  

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Increase Housing Accommodations and Property Values to Serve War Workers

open access: yes, 1942
Pamphlet detailing the United States government's housing conversion program, which would remodel buildings into multi-family housing for war workers at the government's ...
United States. National Housing Agency
core  

The End of the Right to Buy and the Future of Social Housing in Scotland

open access: yes, 2010
Thirty-years after the introduction of the Right to Buy - the most successful example of housing privatisation policy in the UK - the current Housing (Scotland) Bill proposes to end the scheme for both new social housing tenants and new social housing ...
Kim McKee, McKee, Kim
core   +1 more source

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