Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Social policy and housing: reflections of social values [PDF]
This thesis set out to find the correlation between social values and standards in social housing in two major milestones in the developments in state-provided housing.
Manoochehri, J.
core
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
Increase Housing Accommodations and Property Values to Serve War Workers [PDF]
Pamphlet detailing the United States government's housing conversion program, which would remodel buildings into multi-family housing for war workers at the government's ...
United States. National Housing Agency
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The End of the Right to Buy and the Future of Social Housing in Scotland [PDF]
Thirty-years after the introduction of the Right to Buy - the most successful example of housing privatisation policy in the UK - the current Housing (Scotland) Bill proposes to end the scheme for both new social housing tenants and new social housing ...
Kim McKee, McKee, Kim
core +1 more source
Milestones of prefab panel construction at Ukraine: Historical Evolution and Technological Modernization [PDF]
The aim of this paper is a chronological analysis of the development of prefabricated panel technology in Ukraine, which emerged in response to the urgent post-war need for affordable housing and continues to play a significant role in the country's ...
Voloshchuk Dariia +2 more
doaj +1 more source
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Follow the red footprints : souvenir of the Sydney Housing Exhibition, 8th to 28th August, 1944. [PDF]
Cover title.; Electronic reproduction. Canberra, A.C.T.
core
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source

