Results 41 to 50 of about 40,053 (304)

The survival and resurrection of a “Bakema-experiment” in an Amsterdam garden city

open access: yesDocomomo Journal, 2021
There is a hidden gem in the Amsterdam garden cities. Jaap Bakema was the founder of an experiment in the 1950s. A piece of “Rotterdam in Amsterdam.” Based on the philosophy of an open society and the human scale.
Tim Nagtegaal
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Governance and sustainability in Glasgow: connecting symbolic capital and housing consumption to regeneration [PDF]

open access: yes, 2008
To transcend a legacy of slum-living, paternalistic provision and urban decline, Glasgow City Council has endeavoured to transform the city's fortunes by a plethora of mechanisms that have at their core the establishment of sustainable communities ...
McIntyre, Z.   +3 more
core   +1 more source

President Alemán Urban Housing Project

open access: yesDocomomo Journal, 2021
The Centro Urbano Presidente Alemán, inaugurated in 1949, was a pioneer in more ways than one and can be considered as one of the most transcendent works of Mario Pani.
Louise Noelle
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

From Ideal Proposals to Serial Developments: Victor Bourgeois’s Schemes in the Light of Post-War Developments in Brussels

open access: yesUrban Planning, 2019
Three essential elements of modernism consolidated through war: a centralised welfare state, a serial industrial apparatus and, often, a territorial tabula rasa.
Gérald Ledent
doaj   +1 more source

Post-war Reconstruction - Conservation Strategies for the Local Architectural Identity of the Mosul house for the post war

open access: yesSULAIMANI JOURNAL FOR ENGINEERING SCIENCES, 2019
Humanity has witnessed in the past and continues to witness many devastating wars, which showed the weakness of the urban heritage in front of the destructive power of weapons and wars. With the disappearance of several archaeological buildings after the Second World War, the human being started to realize the importance of the local identity and ...
Marwa Mohamed Saeed, Shorsh Salam Hassan
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

La lingua perduta delle gru

open access: yesAnd, 2022
Il 28 febbraio 1949 il Parlamento italiano rende legge il progetto Provvedimenti per incrementare l’occupazione operaia, agevolando la costruzione di case per lavoratori, presentato al Consiglio nel luglio dell’anno precedente dal ministro democristiano
Valter Scelsi
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

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