Results 41 to 50 of about 7,162,910 (287)
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Aspects of Social Sustainability in Planning and Renewal of Housing Estates
Revija za Geografijo, 2011 The chapter highlights a few aspects of social sustainability issues concerning planning and renewal of housing estates, in Slovenia generally comprising of multi-family residential buildings and public buildings, open public space and parking areas.
Vanja Skalicky, Metka Sitar
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
SULAIMANI JOURNAL FOR ENGINEERING SCIENCES, 2019 Humanity has witnessed in the past and continues to witness many devastating wars, which showed the weakness of the urban heritage in front of the destructive power of weapons and wars. With the disappearance of several archaeological buildings after the Second World War, the human being started to realize the importance of the local identity and ...
Marwa Mohamed Saeed, Shorsh Salam Hassan
openaire +2 more sources
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Large Housing Estates in Germany’s Major Cities: A Last Bastion of Affordable Housing?
Urban PlanningThe affordable housing crisis in many major German cities has sparked a new wave of suburbanization. In thriving cities such as Berlin, Cologne, Munich, Frankfurt, and Hamburg, rental prices in central locations have reached unprecedented highs.
Stefan Siedentop +2 more
doaj +1 more source
Social policy and housing: reflections of social values [PDF]
, 2010 This thesis set out to find the correlation between social values and standards in social housing in two major milestones in the developments in state-provided housing.
Manoochehri, J.
core
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
And, 2022 Il 28 febbraio 1949 il Parlamento italiano rende legge il progetto Provvedimenti per incrementare l’occupazione operaia, agevolando la costruzione di case per lavoratori, presentato al Consiglio nel luglio dell’anno precedente dal ministro democristiano
Valter Scelsi
doaj
Urban Planning, 2019 Three essential elements of modernism consolidated through war: a centralised welfare state, a serial industrial apparatus and, often, a territorial tabula rasa.
Gérald Ledent
doaj +1 more source